CYP4B1

CYP4B1
Identifiers
Aliases	CYP4B1, CYPIVB1, P-450HP, cytochrome P450 family 4 subfamily B member 1
External IDs	OMIM: 124075; MGI: 103225; HomoloGene: 128045; GeneCards: CYP4B1; OMA:CYP4B1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	46,819,413 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	115,504,920 bp
RNA expression pattern
	Top expressed in
	bronchial epithelial cell; ; right lung; ; nasal epithelium; ; mucosa of paranasal sinus; ; olfactory zone of nasal mucosa; ; lower lobe of lung; ; epithelium of nasopharynx; ; right uterine tube; ; upper lobe of lung; ; upper lobe of left lung;
	Top expressed in
	right kidney; ; right lung lobe; ; superior surface of tongue; ; human kidney; ; Ileal epithelium; ; olfactory epithelium; ; mesenteric lymph nodes; ; left lung; ; trachea; ; cardiac muscle tissue of left ventricle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	iron ion binding; oxygen binding; metal ion binding; fluorene oxygenase activity; heme binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; oxidoreductase activity; aromatase activity; toxic substance binding; monooxygenase activity;
Cellular component	organelle membrane; endoplasmic reticulum membrane; membrane; intracellular membrane-bounded organelle; endoplasmic reticulum;
Biological process	biphenyl metabolic process; cellular aromatic compound metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	1580
	13120
	ENSG00000142973
	ENSMUSG00000028713
	P13584
	Q64462
	NM_000779; NM_001099772; NM_001319161; NM_001319162; NM_001319163
	NM_007823
	NP_000770; NP_001093242; NP_001306090; NP_001306091; NP_001306092
	NP_031849
	Wikidata
View/Edit Human	View/Edit Mouse

Cytochrome P450 4B1 is a protein that in humans is encoded by the CYP4B1 gene.^[5]

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. In rodents, the homologous protein has been shown to metabolize certain carcinogens; however, the specific function of the human protein has not been determined.^[5]

Mouse Mutant Alleles for Cyp4b1
Marker Symbol for Mouse Gene. This symbol is assigned to the genomic locus by the MGI	Cyp4b1
Mutant Mouse Embryonic Stem Cell Clones. These are the known targeted mutations for this gene in a mouse.	CYP4B1^{tm1a(KOMP)Wtsi}
Example structure of targeted conditional mutant allele for this gene

These Mutant ES Cells can be studied directly or used to generate mice with this gene knocked out. Study of these mice can shed light on the function of Cyp4b1: see Knockout mouse

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000142973 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028713 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000142973 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028713 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1".

[1]

[2]

[3]

[4]

[5]