Calcitonin

CALCA
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCALCA, CT, CGRP-I, CGRP-alpha, KC, PCT, calcitonin related polypeptide alpha, CGRP, CGRP1, CALC1
External IDsOMIM: 114130; MGI: 2151253; HomoloGene: 88401; GeneCards: CALCA; OMA:CALCA - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001033952
NM_001033953
NM_001741
NM_001378949
NM_001378950

NM_001033954
NM_007587
NM_001289444
NM_001305616

RefSeq (protein)

NP_001029125.1

Location (UCSC)Chr 11: 14.97 – 14.97 MbChr 7: 114.23 – 114.24 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Calcitonin is a 32 amino acid peptide hormone secreted by parafollicular cells (also known as C cells) of the thyroid (or endostyle) in humans and other chordates[5] in the ultimopharyngeal body.[6] It acts to reduce blood calcium (Ca2+), opposing the effects of parathyroid hormone (PTH).[7]

Its importance in humans has not been as well established as its importance in other animals, as its function is usually not significant in the regulation of normal calcium homeostasis.[8] It belongs to the calcitonin-like protein family.

Historically calcitonin has also been called thyrocalcitonin.[9]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000110680Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030669Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Sekiguchi T, Kuwasako K, Ogasawara M, Takahashi H, Matsubara S, Osugi T, et al. (January 2016). "Evidence for Conservation of the Calcitonin Superfamily and Activity-regulating Mechanisms in the Basal Chordate Branchiostoma floridae: Insights Into the Molecular and Functional Evolution in Chordates". The Journal of Biological Chemistry. 291 (5): 2345–2356. doi:10.1074/jbc.M115.664003. PMC 4732217. PMID 26644465.
  6. ^ Costoff A. "Sect. 5, Ch. 6: Anatomy, Structure, and Synthesis of Calcitonin (CT)". Endocrinology: hormonal control of calcium and phosphate. Medical College of Georgia. Archived from the original on September 5, 2008. Retrieved 2008-08-07.
  7. ^ Boron WF, Boulpaep EL (2004). "Endocrine system chapter". Medical Physiology: A Cellular And Molecular Approach. Elsevier/Saunders. ISBN 1416023283.
  8. ^ Costoff A. "Sect. 5, Ch. 6: Biological Actions of CT". Medical College of Georgia. Archived from the original on July 5, 2008. Retrieved 2008-08-07.
  9. ^ Felsenfeld AJ, Levine BS (April 2015). "Calcitonin, the forgotten hormone: does it deserve to be forgotten?". Clinical Kidney Journal. 8 (2): 180–187. doi:10.1093/ckj/sfv011. PMC 4370311. PMID 25815174.