California State Route 221

State Route 221 marker
State Route 221
Napa-Vallejo Highway
SR 221 highlighted in red
Route information
Maintained by Caltrans
Length2.682 mi[1] (4.316 km)
Major junctions
South end SR 12 / SR 29 near Napa
North end SR 121 in Napa
Location
CountryUnited States
StateCalifornia
CountiesNapa
Highway system
SR 220 SR 222

State Route 221 (SR 221) is a state highway in the U.S. state of California that runs in and just outside the City of Napa, providing access to Napa Valley College and Napa State Hospital. The highway's southern terminus is with State Route 12 and State Route 29 outside the southeast corner of the city, and its northern terminus is at State Route 121 inside the city. SR 221 forms part of the Napa-Vallejo Highway with SR 29.

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