The Caloosahatchee River is a river on the southwest Gulf Coast of Florida in the United States, approximately 67 miles (108 km) long.[1] It drains rural areas on the northern edge of the Everglades, east of Fort Myers. An important link in the Okeechobee Waterway, a manmade inland waterway system of southern Florida, the river forms a tidal estuary along most of its course and has become the subject of efforts to restore and preserve the Everglades.