Calponin 3, acidic

CNN3
Identifiers
Aliases	CNN3, calponin 3
External IDs	OMIM: 602374; MGI: 1919244; HomoloGene: 37533; GeneCards: CNN3; OMA:CNN3 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	94,927,223 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	121,251,856 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; Achilles tendon; ; ganglionic eminence; ; left adrenal gland; ; right adrenal gland; ; tibial nerve; ; body of uterus; ; left adrenal cortex; ; right adrenal cortex; ; left uterine tube;
	Top expressed in
	endocardial cushion; ; dermis; ; ciliary body; ; iris; ; external carotid artery; ; human fetus; ; atrioventricular valve; ; vestibular sensory epithelium; ; ureter; ; belly cord;
	More reference expression data
	n/a
Gene ontology
Molecular function	microtubule binding; actin binding; calmodulin binding; cadherin binding involved in cell-cell adhesion;
Cellular component	neuronal cell body; dendritic spine; dendrite; postsynaptic density; focal adhesion; actin cytoskeleton; cytosol;
Biological process	negative regulation of ATP-dependent activity; actomyosin structure organization; epithelial cell differentiation; cell-cell adhesion;
	Sources:Amigo / QuickGO
Orthologs
	1266
	71994
	ENSG00000117519
	ENSMUSG00000053931
	Q15417
	Q9DAW9
	NM_001839; NM_001286055; NM_001286056
	NM_028044
	NP_001272984; NP_001272985; NP_001830
	NP_082320
	Wikidata
View/Edit Human	View/Edit Mouse

Calponin 3. acidic is a protein that in humans is encoded by the CNN3 gene.

The CNN3 gene is located at 1p22-p21^[5] in the human chromosomal genome. CNN3 gene contains 7 exons and encodes calponin 3, a 36.4-kDa protein consisting of 329 amino acids with isoelectric point (pI) of 5.84. Calponin 3 is known as acidic calponin. Among three isoforms of calponin, less is known for the gene regulation and function of calponin 3. Nonetheless, much has been learned from extensive studies on the homologous genes CNN1 and CNN2 that encode calponin 1 and calponin 2.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000117519 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000053931 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Maguchi M, Nishida W, Kohara K, Kuwano A, Kondo I, Hiwada K (1995). "Molecular cloning and gene mapping of human basic and acidic calponins". Biochemical and Biophysical Research Communications. 217 (1): 238–44. doi:10.1006/bbrc.1995.2769. PMID 8526917.
^ Liu R, Jin JP (2016). "Calponin Isoforms CNN1, CNN2 and CNN3: Regulators for Actin Cytoskeleton Functions in Smooth Muscle and Non-Muscle Cells". Gene. 585 (1): 143–153. doi:10.1016/j.gene.2016.02.040. PMC 5325697. PMID 26970176.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000117519 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000053931 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8526917-5] Maguchi M, Nishida W, Kohara K, Kuwano A, Kondo I, Hiwada K (1995). "Molecular cloning and gene mapping of human basic and acidic calponins". Biochemical and Biophysical Research Communications. 217 (1): 238–44. doi:10.1006/bbrc.1995.2769. PMID 8526917.

[6] Liu R, Jin JP (2016). "Calponin Isoforms CNN1, CNN2 and CNN3: Regulators for Actin Cytoskeleton Functions in Smooth Muscle and Non-Muscle Cells". Gene. 585 (1): 143–153. doi:10.1016/j.gene.2016.02.040. PMC 5325697. PMID 26970176.

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