Calretinin

CALB2
Identifiers
Aliases	CALB2, CAB29, CAL2, CR, calbindin 2
External IDs	OMIM: 114051; MGI: 101914; HomoloGene: 1318; GeneCards: CALB2; OMA:CALB2 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	71,390,436 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	110,894,842 bp
RNA expression pattern
	Top expressed in
	hypothalamus; ; right hemisphere of cerebellum; ; subcutaneous adipose tissue; ; right adrenal gland; ; right adrenal cortex; ; left adrenal cortex; ; temporal lobe; ; amygdala; ; anterior cingulate cortex; ; substantia nigra;
	Top expressed in
	habenula; ; vestibular membrane of cochlear duct; ; neural layer of retina; ; dentate gyrus of hippocampal formation granule cell; ; olfactory bulb; ; cerebellar cortex; ; ventral tegmental area; ; lobe of cerebellum; ; central gray substance of midbrain; ; ventromedial nucleus;
	More reference expression data
	n/a
Gene ontology
Molecular function	calcium ion binding; metal ion binding; calcium ion binding involved in regulation of presynaptic cytosolic calcium ion concentration;
Cellular component	neuron projection; gap junction; synapse; nucleus; cytoplasm; cytosol; synaptic membrane; parallel fiber to Purkinje cell synapse; presynapse; dendrite; stereocilium; cuticular plate;
Biological process	regulation of cytosolic calcium ion concentration; regulation of presynaptic cytosolic calcium ion concentration; regulation of long-term synaptic potentiation;
	Sources:Amigo / QuickGO
Orthologs
	794
	12308
	ENSG00000172137; ENSG00000282830
	ENSMUSG00000003657
	P22676
	Q08331
	NM_001740; NM_007087; NM_007088
	NM_007586; NM_001368293; NM_001368294
	NP_001731; NP_009019
	NP_031612; NP_001355222; NP_001355223
	Wikidata
View/Edit Human	View/Edit Mouse

Calretinin, also known as calbindin 2 (formerly 29 kDa calbindin), is a calcium-binding protein involved in calcium signaling.^[5] In humans, the calretinin protein is encoded by the CALB2 gene.^[6]^[7]

^ ^a ^b ^c ENSG00000282830 GRCh38: Ensembl release 89: ENSG00000172137, ENSG00000282830 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000003657 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Rogers JH (1987). "Calretinin: a gene for a novel calcium-binding protein expressed principally in neurons". J Cell Biol. 105 (3): 1343–53. doi:10.1083/jcb.105.3.1343. PMC 2114790. PMID 3654755.
^ "Entrez Gene: calbindin 2".
^ Parmentier M, Passage E, Vassart G, Mattei MG (1991). "The human calbindin D28k (CALB1) and calretinin (CALB2) genes are located at 8q21.3----q22.1 and 16q22----q23, respectively, suggesting a common duplication with the carbonic anhydrase isozyme loci". Cytogenetics and Cell Genetics. 57 (1): 41–3. doi:10.1159/000133111. PMID 1906795.

[refGRCh38Ensembl-1] ENSG00000282830 GRCh38: Ensembl release 89: ENSG00000172137, ENSG00000282830 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000003657 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid3654755-5] Rogers JH (1987). "Calretinin: a gene for a novel calcium-binding protein expressed principally in neurons". J Cell Biol. 105 (3): 1343–53. doi:10.1083/jcb.105.3.1343. PMC 2114790. PMID 3654755.

[entrez-6] "Entrez Gene: calbindin 2".

[pmid1906795-7] Parmentier M, Passage E, Vassart G, Mattei MG (1991). "The human calbindin D28k (CALB1) and calretinin (CALB2) genes are located at 8q21.3----q22.1 and 16q22----q23, respectively, suggesting a common duplication with the carbonic anhydrase isozyme loci". Cytogenetics and Cell Genetics. 57 (1): 41–3. doi:10.1159/000133111. PMID 1906795.

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