Camazepam

Not to be confused with clonazepam, clobazam, or cinolazepam.
Camazepam
Clinical data
Pregnancy
category
  • ?
Routes of
administration		Oral
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability90%
MetabolismHepatic
Elimination half-life6,4-10,5 hours
ExcretionRenal
Identifiers
  • 7-chloro-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl N,N-dimethylcarbamate
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.048.046 Edit this at Wikidata
Chemical and physical data
FormulaC19H18ClN3O3
Molar mass371.82 g·mol−1
3D model (JSmol)
  • ClC1=CC2=C(C=C1)N(C)C(C(N=C2C3=CC=CC=C3)OC(N(C)C)=O)=O
  • InChI=1S/C19H18ClN3O3/c1-22(2)19(25)26-17-18(24)23(3)15-10-9-13(20)11-14(15)16(21-17)12-7-5-4-6-8-12/h4-11,17H,1-3H3 checkY
  • Key:PXBVEXGRHZFEOF-UHFFFAOYSA-N checkY
  (verify)

Camazepam[2] is a benzodiazepine psychoactive drug, marketed under the brand names Albego, Limpidon and Paxor. It is the dimethyl carbamate ester of temazepam, a metabolite of diazepam.[3] While it possesses anxiolytic, anticonvulsant, skeletal muscle relaxant and hypnotic properties[4] it differs from other benzodiazepines in that its anxiolytic properties are particularly prominent but has comparatively limited anticonvulsant, hypnotic and skeletal muscle relaxant properties.

  1. ^ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
  2. ^ DE 2142181, "1,4 Benzodiazepine derivatives and process for their production", issued 23 December 1976, assigned to Siphar S A , Lugano (Schweiz). 
  3. ^ Tammaro A, Picceo MT, Gemmellaro P, Bonaccorso O (1977). "Camazepam versus placebo. A double-blind clinical study on geriatric patients suffering from psychic complaints. Short Communication". Arzneimittel-Forschung. 27 (11): 2177–2178. PMID 23793.
  4. ^ Lu XL, Yang SK (April 1994). "Enantiomer resolution of camazepam and its derivatives and enantioselective metabolism of camazepam by human liver microsomes". Journal of Chromatography A. 666 (1–2): 249–257. doi:10.1016/0021-9673(94)80387-0. PMID 7911374.