Cantrell is a surname of English and French origin. Notable people with the surname include:
- Cantrell (rapper), American hip-hop artist
- Arthur Cantrell (1883–1954), English cricketer and Royal Marines officer
- Cantrell (Middlesex cricketer)
- Blu Cantrell, R&B singer
- Cady Cantrell, model
- Charles P. Cantrell, American Medal of Honor recipient
- Dylan Cantrell (born 1994), American football player
- Frédérique Cantrel (fl. 1969–present), French actress
- Gary Cantrell, aka Lazarus Lake, American endurance race designer and director
- Hunter Cantrell, American politician
- Jerry Cantrell, guitarist from the band Alice in Chains
- Julie Cantrell, American author and editor
- Lana Cantrell, Australian-American singer, lawyer, Order of Australia awardee
- LaToya Cantrell, American politician currently serving as the Mayor of New Orleans
- Laura Cantrell, singer and DJ
- Norda Cantrell, another name for the comic character Northwind
- Paul Cantrell (1895–1962), American businessman and politician
- Peter Cantrell, cricketer
- Will Cantrell, character in the movie Dark Command