Cape Shirreff is a prominent cape at the north end of the rocky peninsula which separates Hero Bay and Barclay Bay on the north coast of Livingston Island, in the South Shetland Islands of Antarctica. The cape was named by Edward Bransfield in 1820 after Captain William H. Shirreff, the British commanding officer in the Pacific at that time.
The seasonal scientific field station Doctor Guillermo Mann Base has been operated by Chile since 1991 and the Shirreff Base (now Holt Watters Field Camp) by the USA since 1996.