| CBM_1 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 three-dimensional structures of three engineered cellulose-binding domains of cellobiohydrolase i from trichoderma reesei, nmr, 18 structures | |||||||||
| Identifiers | |||||||||
| Symbol | CBM_1 | ||||||||
| Pfam | PF00734 | ||||||||
| Pfam clan | CL0083 | ||||||||
| ECOD | 387.1.1 | ||||||||
| InterPro | IPR000254 | ||||||||
| PROSITE | PDOC00486 | ||||||||
| SCOP2 | 1cel / SCOPe / SUPFAM | ||||||||
| CAZy | CBM1 | ||||||||
| |||||||||
| CBM_2 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 solution structure of a cellulose binding domain from cellulomonas fimi by nuclear magnetic resonance spectroscopy | |||||||||
| Identifiers | |||||||||
| Symbol | CBM_2 | ||||||||
| Pfam | PF00553 | ||||||||
| Pfam clan | CL0203 | ||||||||
| ECOD | 11.1.5 | ||||||||
| InterPro | IPR001919 | ||||||||
| PROSITE | PDOC00485 | ||||||||
| SCOP2 | 1exg / SCOPe / SUPFAM | ||||||||
| CAZy | CBM2 | ||||||||
| |||||||||
| CBM_3 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 crystal structure of a family iiia cbd from clostridium cellulolyticum | |||||||||
| Identifiers | |||||||||
| Symbol | CBM_3 | ||||||||
| Pfam | PF00942 | ||||||||
| Pfam clan | CL0203 | ||||||||
| ECOD | 11.1.5 | ||||||||
| InterPro | IPR001956 | ||||||||
| SCOP2 | 1nbc / SCOPe / SUPFAM | ||||||||
| CAZy | CBM3 | ||||||||
| |||||||||
| CBM_5/12 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 interactions of a family 18 chitinase with the designed inhibitor hm508, and its degradation product, chitobiono-delta-lactone | |||||||||
| Identifiers | |||||||||
| Symbol | CBM_5_12 | ||||||||
| Pfam | PF02839 | ||||||||
| ECOD | 64.3.1 | ||||||||
| InterPro | IPR003610 | ||||||||
| SCOP2 | 1ed7 / SCOPe / SUPFAM | ||||||||
| CAZy | CBM12 | ||||||||
| |||||||||
| CBM_6 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 cbm6ct from clostridium thermocellum in complex with xylopentaose | |||||||||
| Identifiers | |||||||||
| Symbol | CBM_6 | ||||||||
| Pfam | PF03422 | ||||||||
| Pfam clan | CL0202 | ||||||||
| ECOD | 10.32.1 | ||||||||
| InterPro | IPR005084 | ||||||||
| SCOP2 | 1gmm / SCOPe / SUPFAM | ||||||||
| CAZy | CBM6 | ||||||||
| |||||||||
| CBM_4/9 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 cbm4 structure and function | |||||||||
| Identifiers | |||||||||
| Symbol | CBM_4_9 | ||||||||
| Pfam | PF02018 | ||||||||
| Pfam clan | CL0202 | ||||||||
| ECOD | 10.32.1 | ||||||||
| InterPro | IPR003305 | ||||||||
| SCOP2 | 1ulp / SCOPe / SUPFAM | ||||||||
| CAZy | CBM22 | ||||||||
| |||||||||
| CBM_10 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 solution structure of type x cbm | |||||||||
| Identifiers | |||||||||
| Symbol | CBM_10 | ||||||||
| Pfam | PF02013 | ||||||||
| ECOD | 908.1.1 | ||||||||
| InterPro | IPR002883 | ||||||||
| SCOP2 | 1qld / SCOPe / SUPFAM | ||||||||
| CAZy | CBM10 | ||||||||
| |||||||||
| CBM_11 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 family 11 carbohydrate-binding module of cellulosomal cellulase lic26a-cel5e of clostridium thermocellum | |||||||||
| Identifiers | |||||||||
| Symbol | CBM_11 | ||||||||
| Pfam | PF03425 | ||||||||
| Pfam clan | CL0202 | ||||||||
| ECOD | 10.32.1 | ||||||||
| InterPro | IPR005087 | ||||||||
| CAZy | CBM11 | ||||||||
| |||||||||
| CBM_14 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | CBM_14 | ||||||||
| Pfam | PF01607 | ||||||||
| Pfam clan | CL0155 | ||||||||
| ECOD | 394.1.1 | ||||||||
| InterPro | IPR002557 | ||||||||
| SCOP2 | 1dqc / SCOPe / SUPFAM | ||||||||
| CAZy | CBM14 | ||||||||
| |||||||||
| CBM_15 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 xylan-binding module cbm15 | |||||||||
| Identifiers | |||||||||
| Symbol | CBM_15 | ||||||||
| Pfam | PF03426 | ||||||||
| Pfam clan | CL0202 | ||||||||
| ECOD | 10.32.1 | ||||||||
| InterPro | IPR005088 | ||||||||
| SCOP2 | 1gny / SCOPe / SUPFAM | ||||||||
| CAZy | CBM15 | ||||||||
| |||||||||
| CBM_17/28 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 structure of fam17 carbohydrate binding module from clostridium cellulovorans | |||||||||
| Identifiers | |||||||||
| Symbol | CBM_17_28 | ||||||||
| Pfam | PF03424 | ||||||||
| Pfam clan | CL0202 | ||||||||
| ECOD | 10.32.1 | ||||||||
| InterPro | IPR005086 | ||||||||
| SCOP2 | 1g0c / SCOPe / SUPFAM | ||||||||
| CAZy | CBM28 | ||||||||
| |||||||||
| Chitin_bind_1 (CBM18) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 crystal structure analysis of crosslinked-wga3/glcnacbeta1,4glcnac complex | |||||||||
| Identifiers | |||||||||
| Symbol | Chitin_bind_1 | ||||||||
| Pfam | PF00187 | ||||||||
| ECOD | 387.1.2 | ||||||||
| InterPro | IPR001002 | ||||||||
| PROSITE | PDOC00025 | ||||||||
| SCOP2 | 1wgt / SCOPe / SUPFAM | ||||||||
| CAZy | CBM18 | ||||||||
| |||||||||
| CBM_19 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | CBM_19 | ||||||||
| Pfam | PF03427 | ||||||||
| Pfam clan | CL0155 | ||||||||
| InterPro | IPR005089 | ||||||||
| CAZy | CBM19 | ||||||||
| |||||||||
| CBM_20 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 glucoamylase, granular starch-binding domain complex with cyclodextrin, nmr, minimized average structure | |||||||||
| Identifiers | |||||||||
| Symbol | CBM_20 | ||||||||
| Pfam | PF00686 | ||||||||
| Pfam clan | CL0369 | ||||||||
| ECOD | 11.1.4 | ||||||||
| InterPro | IPR002044 | ||||||||
| SCOP2 | 1cdg / SCOPe / SUPFAM | ||||||||
| CAZy | CBM20 | ||||||||
| |||||||||
| CBM_21 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | CBM_21 | ||||||||
| Pfam | PF03370 | ||||||||
| ECOD | 11.1.1 | ||||||||
| InterPro | IPR005036 | ||||||||
| CAZy | CBM21 | ||||||||
| |||||||||
| CBM_25 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | CBM_25 | ||||||||
| Pfam | PF03423 | ||||||||
| ECOD | 11.1.4 | ||||||||
| InterPro | IPR005085 | ||||||||
| CAZy | CBM25 | ||||||||
| |||||||||
| CBM27 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 structural and thermodynamic dissection of specific mannan recognition by a carbohydrate-binding module, tmcbm27 | |||||||||
| Identifiers | |||||||||
| Symbol | CBM27 | ||||||||
| Pfam | PF09212 | ||||||||
| ECOD | 10.32.1 | ||||||||
| InterPro | IPR015295 | ||||||||
| SCOP2 | 1oh4 / SCOPe / SUPFAM | ||||||||
| |||||||||
| Chitin_bind_3 (CBM33) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 crystal structure of the serratia marcescens chitin-binding protein cbp21 y54a mutant. | |||||||||
| Identifiers | |||||||||
| Symbol | Chitin_bind_3 | ||||||||
| Pfam | PF03067 | ||||||||
| Pfam clan | CL0159 | ||||||||
| ECOD | 11.1.1 | ||||||||
| InterPro | IPR004302 | ||||||||
| CAZy | CBM33 | ||||||||
| |||||||||
| CBM_48 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 crystal structure of glycosyltrehalose trehalohydrolase from sulfolobus solfataricus | |||||||||
| Identifiers | |||||||||
| Symbol | CBM_48 | ||||||||
| Pfam | PF02922 | ||||||||
| Pfam clan | CL0369 | ||||||||
| ECOD | 11.1.1 | ||||||||
| InterPro | IPR004193 | ||||||||
| SCOP2 | 1bf2 / SCOPe / SUPFAM | ||||||||
| CAZy | CBM48 | ||||||||
| |||||||||
| CBM49 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | CBM49 | ||||||||
| Pfam | PF09478 | ||||||||
| Pfam clan | CL0203 | ||||||||
| InterPro | IPR019028 | ||||||||
| |||||||||
In molecular biology, a carbohydrate-binding module (CBM) is a protein domain found in carbohydrate-active enzymes (for example glycoside hydrolases). The majority of these domains have carbohydrate-binding activity. Some of these domains are found on cellulosomal scaffoldin proteins. CBMs were previously known as cellulose-binding domains.[1] CBMs are classified into numerous families, based on amino acid sequence similarity. There are currently (June 2011) 64 families of CBM in the CAZy database.[2]
CBMs of microbial glycoside hydrolases play a central role in the recycling of photosynthetically fixed carbon through their binding to specific plant structural polysaccharides.[3] CBMs can recognise both crystalline and amorphous cellulose forms.[4] CBMs are the most common non-catalytic modules associated with enzymes active in plant cell-wall hydrolysis. Many putative CBMs have been identified by amino acid sequence alignments but only a few representatives have been shown experimentally to have a carbohydrate-binding function.[5]
- ^ Gilkes NR, Henrissat B, Kilburn DG, Miller RC, Warren RA (June 1991). "Domains in microbial beta-1, 4-glycanases: sequence conservation, function, and enzyme families". Microbiol. Rev. 55 (2): 303–15. doi:10.1128/MMBR.55.2.303-315.1991. PMC 372816. PMID 1886523.
- ^ Cantarel, B. L.; Coutinho, P. M.; Rancurel, C.; Bernard, T.; Lombard, V.; Henrissat, B. (2009). "The Carbohydrate-Active EnZymes database (CAZy): An expert resource for Glycogenomics". Nucleic Acids Research. 37 (Database issue): D233–D238. doi:10.1093/nar/gkn663. PMC 2686590. PMID 18838391.
- ^ Cite error: The named reference
pmid11598143was invoked but never defined (see the help page). - ^ Jamal S, Nurizzo D, Boraston AB, Davies GJ (May 2004). "X-ray crystal structure of a non-crystalline cellulose-specific carbohydrate-binding module: CBM28". J. Mol. Biol. 339 (2): 253–8. doi:10.1016/j.jmb.2004.03.069. PMID 15136030.
- ^ Roske Y, Sunna A, Pfeil W, Heinemann U (July 2004). "High-resolution crystal structures of Caldicellulosiruptor strain Rt8B.4 carbohydrate-binding module CBM27-1 and its complex with mannohexaose". J. Mol. Biol. 340 (3): 543–54. doi:10.1016/j.jmb.2004.04.072. PMID 15210353.