Cardiotoxicity

Cardiotoxicity is the occurrence of heart dysfunction as electric or muscle damage, resulting in heart toxicity.[1] This can cause heart failure, arrhythmia, myocarditis, and cardiomyopathy in patients.[2] Some effects are reversible, while in others, permanent damage requiring further treatment may arise. The heart becomes weaker and is not as efficient in pumping blood. Cardiotoxicity may be caused by chemotherapy (a usual example is the class of anthracyclines)[3][4] treatment and/or radiotherapy;[5] complications from anorexia nervosa; adverse effects of heavy metals intake;[6] the long-term abuse of or ingestion at high doses of certain strong stimulants such as cocaine;[7] or an incorrectly administered drug such as bupivacaine.[8]

  1. ^ Sishi, Balindiwe J. N. (2015-01-01), Hayat, M. A. (ed.), "Chapter 10 - Autophagy Upregulation Reduces Doxorubicin-Induced Cardiotoxicity", Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging, Amsterdam: Academic Press, pp. 157–173, doi:10.1016/b978-0-12-801033-4.00010-2, ISBN 978-0-12-801033-4, retrieved 2022-07-06
  2. ^ Herrmann, Joerg (August 2020). "Adverse cardiac effects of cancer therapies: cardiotoxicity and arrhythmia". Nature Reviews Cardiology. 17 (8): 474–502. doi:10.1038/s41569-020-0348-1. ISSN 1759-5002. PMC 8782611. PMID 32231332.
  3. ^ Huang, C.; Zhang, X.; Ramil, J. M.; Rikka, S.; Kim, L.; Lee, Y.; Gude, N. A.; Thistlethwaite, P. A.; Sussman, M. A. (2010). "Juvenile Exposure to Anthracyclines Impairs Cardiac Progenitor Cell Function and Vascularization Resulting in Greater Susceptibility to Stress-Induced Myocardial Injury in Adult Mice. Cardiotoxins are the second most toxic venom while neurotoxins are the first". Circulation. 121 (5): 675–83. doi:10.1161/CIRCULATIONAHA.109.902221. PMC 2834271. PMID 20100968.
  4. ^ Volkova M, Russell R (2011). "Anthracycline Cardiotoxicity: Prevalence, Pathogenesis and Treatment". Curr Cardiol Rev. 7 (4): 214–220. doi:10.2174/157340311799960645. PMC 3322439. PMID 22758622.
  5. ^ Suchorska, Wiktoria M. (2020-01-01). "Radiobiological models in prediction of radiation cardiotoxicity". Reports of Practical Oncology & Radiotherapy. 25 (1): 46–49. doi:10.1016/j.rpor.2019.12.001. ISSN 1507-1367. PMC 6931197. PMID 31889920.
  6. ^ Nigra, Anne E; Ruiz-Hernandez, Adrian; Redon, Josep; Navas-Acien, Ana; Tellez-Plaza, Maria (2016). "Environmental Metals and Cardiovascular Disease in Adults: A Systematic Review beyond Lead and Cadmium". Current Environmental Health Reports. 3 (4): 416–433. doi:10.1007/s40572-016-0117-9. ISSN 2196-5412. PMC 5801549. PMID 27783356.
  7. ^ Pergolizzi, Joseph V; Magnusson, Peter; LeQuang, Jo Ann K; Breve, Frank; Varrassi, Giustino (2021). "Cocaine and Cardiotoxicity: A Literature Review". Cureus. 13 (4): e14594. doi:10.7759/cureus.14594. ISSN 2168-8184. PMC 8136464. PMID 34036012.
  8. ^ de La Coussaye JE, Eledjam JJ, Brugada J, Sassine A (1993). "[Cardiotoxicity of local anesthetics]". Cahiers d'Anesthésiologie. 41 (6): 589–598. PMID 8287299.