The Carhuasanta is a small river located in the Arequipa Region of Peru. It is known as the headwaters of the Amazon River. The brook is fed by the winter snows of Nevado Mismi, (5,597 m), some 6,400 kilometers from the Atlantic Ocean. Of all the possible river sources in the Amazon Basin, it is the snow melt of the Carhuasanta that has been calculated by cartographers to be one of the furthermost water sources from the mouth of the Amazon.
The Carhuasanta joins with the Quebrada Apacheta, becoming the Rio Lloqueta. The river has several more name changes before it becomes the Apurímac River. The mining town of Caylloma lies near the junction of four rivers that form the Apurímac river.