Casein kinase 2

Casein kinase 2 (EC 2.7.11.1)(CK2/CSNK2) is a serine/threonine-selective protein kinase that has been implicated in cell cycle control, DNA repair, regulation of the circadian rhythm, and other cellular processes. De-regulation of CK2 has been linked to tumorigenesis as a potential protection mechanism for mutated cells. Proper CK2 function is necessary for survival of cells as no knockout models have been successfully generated.[1]

  1. ^ Ahmad KA, Wang G, Unger G, Slaton J, Ahmed K (2008). "Protein kinase CK2--a key suppressor of apoptosis". Advances in Enzyme Regulation. 48: 179–187. doi:10.1016/j.advenzreg.2008.04.002. PMC 2593134. PMID 18492491.