Caspase 6

CASP6
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2WDP, 3K7E, 3NKF, 3NR2, 3OD5, 3P45, 3P4U, 3QNW, 3S70, 3S8E, 3V6L, 3V6M, 4EJF, 4FXO, 4HVA, 4IYR, 4N5D, 4N6G, 4N7J, 4N7M, 4NBK, 4NBL, 4NBN
Identifiers
Aliases	CASP6, MCH2, Caspase 6, CSP-6
External IDs	OMIM: 601532; MGI: 1312921; HomoloGene: 37455; GeneCards: CASP6; OMA:CASP6 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	109,703,583 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	129,707,752 bp
RNA expression pattern
	Top expressed in
	rectum; ; mucosa of transverse colon; ; oocyte; ; secondary oocyte; ; jejunal mucosa; ; duodenum; ; pancreatic ductal cell; ; mucosa of sigmoid colon; ; buccal mucosa cell; ; islet of Langerhans;
	Top expressed in
	gastric mucosa; ; epithelium of stomach; ; mucous cell of stomach; ; pyloric antrum; ; duodenum; ; jejunum; ; endocardial cushion; ; migratory enteric neural crest cell; ; yolk sac; ; parotid gland;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	peptidase activity; cysteine-type endopeptidase activity; cysteine-type peptidase activity; endopeptidase activity; protein binding; hydrolase activity; identical protein binding; cysteine-type endopeptidase activity involved in execution phase of apoptosis; cysteine-type endopeptidase activity involved in apoptotic process;
Cellular component	cytosol; nucleoplasm; cytoplasm;
Biological process	epithelial cell differentiation; proteolysis; apoptotic process; regulation of apoptotic process; execution phase of apoptosis; cellular response to staurosporine;
	Sources:Amigo / QuickGO
Orthologs
	839
	12368
	ENSG00000138794
	ENSMUSG00000027997
	P55212
	O08738
	NM_001226; NM_032992
	NM_009811
	NP_001217; NP_116787
	NP_033941
	Wikidata
View/Edit Human	View/Edit Mouse

Caspase-6 is an enzyme that in humans is encoded by the CASP6 gene.^[5]^[6] CASP6 orthologs^[7] have been identified in numerous mammals for which complete genome data are available. Unique orthologs are also present in birds, lizards, lissamphibians, and teleosts. Caspase-6 has known functions in apoptosis,^[8] early immune response^[9]^[10] and neurodegeneration in Huntington's and Alzheimer's disease.^[11]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000138794 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027997 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Tiso N, Pallavicini A, Muraro T, Zimbello R, Apolloni E, Valle G, Lanfranchi G, Danieli GA (Oct 1996). "Chromosomal localization of the human genes, CPP32, Mch2, Mch3, and Ich-1, involved in cellular apoptosis". Biochem Biophys Res Commun. 225 (3): 983–9. doi:10.1006/bbrc.1996.1282. hdl:11577/2461073. PMID 8780721.
^ Fernandes-Alnemri T, Litwack G, Alnemri ES (Aug 1995). "Mch2, a new member of the apoptotic Ced-3/Ice cysteine protease gene family". Cancer Res. 55 (13): 2737–42. PMID 7796396.
^ "OrthoMaM phylogenetic marker: CASP6 coding sequence". Archived from the original on 2016-03-03. Retrieved 2009-12-20.
^ Cohen, Gerald M. (1997-08-15). "Caspases: the executioners of apoptosis". Biochemical Journal. 326 (1): 1–16. doi:10.1042/bj3260001. ISSN 0264-6021. PMC 1218630. PMID 9337844.
^ Bartel, Alexander; Göhler, André; Hopf, Verena; Breitbach, Katrin (2017-07-07). "Caspase-6 mediates resistance against Burkholderia pseudomallei infection and influences the expression of detrimental cytokines". PLOS ONE. 12 (7): e0180203. Bibcode:2017PLoSO..1280203B. doi:10.1371/journal.pone.0180203. ISSN 1932-6203. PMC 5501493. PMID 28686630.
^ Kobayashi, Hiroshi; Nolan, Anna; Naveed, Bushra; Hoshino, Yoshihiko; Segal, Leopoldo N.; Fujita, Yoko; Rom, William N.; Weiden, Michael D. (2011-01-01). "Neutrophils Activate Alveolar Macrophages by Producing Caspase-6–Mediated Cleavage of IL-1 Receptor-Associated Kinase-M". The Journal of Immunology. 186 (1): 403–410. doi:10.4049/jimmunol.1001906. ISSN 0022-1767. PMC 3151149. PMID 21098228.
^ Graham, Rona K.; Ehrnhoefer, Dagmar E.; Hayden, Michael R. (2011-12-01). "Caspase-6 and neurodegeneration". Trends in Neurosciences. 34 (12): 646–656. doi:10.1016/j.tins.2011.09.001. ISSN 0166-2236. PMID 22018804. S2CID 1603684.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000138794 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027997 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8780721-5] Tiso N, Pallavicini A, Muraro T, Zimbello R, Apolloni E, Valle G, Lanfranchi G, Danieli GA (Oct 1996). "Chromosomal localization of the human genes, CPP32, Mch2, Mch3, and Ich-1, involved in cellular apoptosis". Biochem Biophys Res Commun. 225 (3): 983–9. doi:10.1006/bbrc.1996.1282. hdl:11577/2461073. PMID 8780721.

[pmid7796396-6] Fernandes-Alnemri T, Litwack G, Alnemri ES (Aug 1995). "Mch2, a new member of the apoptotic Ced-3/Ice cysteine protease gene family". Cancer Res. 55 (13): 2737–42. PMID 7796396.

[OrthoMaM-7] "OrthoMaM phylogenetic marker: CASP6 coding sequence". Archived from the original on 2016-03-03. Retrieved 2009-12-20.

[:0-8] Cohen, Gerald M. (1997-08-15). "Caspases: the executioners of apoptosis". Biochemical Journal. 326 (1): 1–16. doi:10.1042/bj3260001. ISSN 0264-6021. PMC 1218630. PMID 9337844.

[:1-9] Bartel, Alexander; Göhler, André; Hopf, Verena; Breitbach, Katrin (2017-07-07). "Caspase-6 mediates resistance against Burkholderia pseudomallei infection and influences the expression of detrimental cytokines". PLOS ONE. 12 (7): e0180203. Bibcode:2017PLoSO..1280203B. doi:10.1371/journal.pone.0180203. ISSN 1932-6203. PMC 5501493. PMID 28686630.

[:2-10] Kobayashi, Hiroshi; Nolan, Anna; Naveed, Bushra; Hoshino, Yoshihiko; Segal, Leopoldo N.; Fujita, Yoko; Rom, William N.; Weiden, Michael D. (2011-01-01). "Neutrophils Activate Alveolar Macrophages by Producing Caspase-6–Mediated Cleavage of IL-1 Receptor-Associated Kinase-M". The Journal of Immunology. 186 (1): 403–410. doi:10.4049/jimmunol.1001906. ISSN 0022-1767. PMC 3151149. PMID 21098228.

[:3-11] Graham, Rona K.; Ehrnhoefer, Dagmar E.; Hayden, Michael R. (2011-12-01). "Caspase-6 and neurodegeneration". Trends in Neurosciences. 34 (12): 646–656. doi:10.1016/j.tins.2011.09.001. ISSN 0166-2236. PMID 22018804. S2CID 1603684.

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