Catenin

Interactions of structural proteins at cadherin-based adherens junction. The exact means by which cadherins are linked to actin filaments is still under investigation.[1]

Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells. The first two catenins that were identified[2] became known as α-catenin and β-catenin. α-Catenin can bind to β-catenin and can also bind filamentous actin (F-actin).[3] β-Catenin binds directly to the cytoplasmic tail of classical cadherins. Additional catenins such as γ-catenin and δ-catenin have been identified. The name "catenin" was originally selected ('catena' means 'chain' in Latin) because it was suspected that catenins might link cadherins to the cytoskeleton.[4]

  1. ^ Weis WI, Nelson WJ (November 2006). "Re-solving the cadherin-catenin-actin conundrum". J. Biol. Chem. 281 (47): 35593–7. doi:10.1074/jbc.R600027200. PMC 3368706. PMID 17005550.
  2. ^ Peyriéras N, Louvard D, Jacob F (December 1985). "Characterization of antigens recognized by monoclonal and polyclonal antibodies directed against uvomorulin". Proc. Natl. Acad. Sci. U.S.A. 82 (23): 8067–71. Bibcode:1985PNAS...82.8067P. doi:10.1073/pnas.82.23.8067. PMC 391443. PMID 2415979.
  3. ^ Buckley, Craig D.; Tan, Jiongyi; Anderson, Karen L.; Hanein, Dorit; Volkmann, Niels; Weis, William I.; Nelson, W. James; Dunn, Alexander R. (2014-10-31). "Cell adhesion. The minimal cadherin-catenin complex binds to actin filaments under force". Science. 346 (6209): 1254211. doi:10.1126/science.1254211. ISSN 1095-9203. PMC 4364042. PMID 25359979.
  4. ^ Ozawa M, Baribault H, Kemler R (June 1989). "The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species". EMBO J. 8 (6): 1711–7. doi:10.1002/j.1460-2075.1989.tb03563.x. PMC 401013. PMID 2788574.