Cav1.3

CACNA1D
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3LV3
Identifiers
Aliases	CACNA1D, CACH3, CACN4, CACNL1A2, CCHL1A2, Cav1.3, PASNA, SANDD, calcium voltage-gated channel subunit alpha1 D
External IDs	OMIM: 114206; MGI: 88293; HomoloGene: 578; GeneCards: CACNA1D; OMA:CACNA1D - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p21.1 Start 53,328,963 bp[1] End 53,813,733 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14 A3- B|14 18.43 cM Start 29,761,896 bp[2] End 30,213,412 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell right lung sural nerve right adrenal gland islet of Langerhans right adrenal cortex left adrenal cortex pituitary gland right uterine tube testicle Top expressed in pituitary gland superior frontal gyrus substantia nigra utricle islet of Langerhans primary visual cortex pineal gland stria vascularis suprachiasmatic nucleus vas deferens More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding voltage-gated ion channel activity high voltage-gated calcium channel activity ion channel activity voltage-gated calcium channel activity involved in cardiac muscle cell action potential alpha-actinin binding ankyrin binding voltage-gated calcium channel activity voltage-gated calcium channel activity involved SA node cell action potential calcium channel activity voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels Cellular component voltage-gated calcium channel complex L-type voltage-gated calcium channel complex integral component of membrane membrane plasma membrane Z discdkac cochlear hair cell ribbon synapse integral component of presynaptic active zone membrane Biological process regulation of atrial cardiac muscle cell membrane repolarization regulation of insulin secretion adenylate cyclase-modulating G protein-coupled receptor signaling pathway calcium ion import regulation of ion transmembrane transport ion transport calcium ion transmembrane transport transmembrane transport regulation of potassium ion transmembrane transporter activity membrane depolarization during cardiac muscle cell action potential regulation of potassium ion transmembrane transport calcium ion transport positive regulation of calcium ion transport hearing cardiac muscle cell action potential involved in contraction membrane depolarization during SA node cell action potential regulation of heart rate by cardiac conduction positive regulation of presynaptic cytosolic calcium concentration induction of synaptic vesicle exocytosis by positive regulation of presynaptic cytosolic calcium ion concentration positive regulation of adenylate cyclase activity cardiac conduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 776 12289 Ensembl ENSG00000157388 ENSMUSG00000015968 UniProt Q01668 Q99246 RefSeq (mRNA) NM_000720 NM_001128839 NM_001128840 NM_001083616 NM_028981 NM_001302637 RefSeq (protein) NP_000711 NP_001122311 NP_001122312 NP_001077085 NP_001289566 NP_083257 Location (UCSC) Chr 3: 53.33 – 53.81 Mb Chr 14: 29.76 – 30.21 Mb PubMed search [3] [4]
Wikidata
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Calcium channel, voltage-dependent, L type, alpha 1D subunit (also known as Ca_v1.3) is a protein that in humans is encoded by the CACNA1D gene.^[5] Ca_v1.3 channels belong to the Ca_v1 family, which form L-type calcium currents and are sensitive to selective inhibition by dihydropyridines (DHP).