Cayuse

Cayuse may refer to:

• Cayuse people, a people native to Oregon, United States
• Cayuse language, an extinct language of the Cayuse people
• Cayuse, Oregon, an unincorporated community in the United States
• Cayuse horse, an archaic term for a feral or low-quality horse or pony
• OH-6 "Cayuse", a military observation helicopter
• Cayuse Five, five Cayuse who were hanged for murder