Cell division control protein 4

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Structures	Swiss-model
Domains	InterPro

Cdc4
Cdc4
	Crystal structure of Cdc4
Identifiers
Symbol	Cdc4
Alt. symbols	cell division control protein 4
NCBI gene	850539
UniProt	P07834
Structures
Search for
Structures	Swiss-model
Domains	InterPro

Cdc4 (cell division control protein 4) is a substrate recognition component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which acts as a mediator of ubiquitin transfer to target proteins, leading to their subsequent degradation via the ubiquitin-proteasome pathway. Cdc4 targets primarily cell cycle regulators for proteolysis. It serves the function of an adaptor that brings target molecules to the core SCF complex. Cdc4 was originally identified in the model organism Saccharomyces cerevisiae. CDC4 gene function is required at G1/S and G2/M transitions during mitosis and at various stages during meiosis.^[1]

^ Simchen G, Hirschberg J (May 1977). "Effects of the mitotic cell-cycle mutation cdc4 on yeast meiosis". Genetics. 86 (1): 57–72. doi:10.1093/genetics/86.1.57. PMC 1213672. PMID 328339.

[Simchen-1] Simchen G, Hirschberg J (May 1977). "Effects of the mitotic cell-cycle mutation cdc4 on yeast meiosis". Genetics. 86 (1): 57–72. doi:10.1093/genetics/86.1.57. PMC 1213672. PMID 328339.

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