Centaurus is a bright constellation in the southern sky.
Centaurus may also refer to:
- Centaurus (Greek mythology), father of the race of mythological beasts
- Centaurus (journal), of the European Society for the History of Science
- Centaurus (spacecraft mission), a proposed NASA program
- Centaurus (virus), a subvariant of the Omicron variant of SARS-CoV-2
- Bristol Centaurus, a 1938 aircraft engine
- SS Centaurus, a cargo ship, later SS Portmar
- USS Centaurus, the named of two ships of the U.S. Navy
- Centaurus Advisors, a hedge fund run by John D. Arnold
- The Centaurus, a building complex in Islamabad, Pakistan
- Centaurus High School, in Lafayette, Colorado, U.S.
- Centaurus Secondary School, in Windhoek, Namibia