Ceritinib

Ceritinib
Clinical data
Pronunciation/səˈrɪtɪnɪb/ sə-RIT-i-nib
Trade namesZykadia, others
Other namesLDK378
AHFS/Drugs.comMonograph
MedlinePlusa614027
License data
Routes of
administration		By mouth
ATC code
Legal status
Legal status
Pharmacokinetic data
BioavailabilityNot determined
Protein binding97%
MetabolismCYP3A
Elimination half-life41 hours
ExcretionFeces (92.3%), urine (1.3%)[5]
Identifiers
  • 5-Chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
PDB ligand
CompTox Dashboard (EPA)
ECHA InfoCard100.241.919 Edit this at Wikidata
Chemical and physical data
FormulaC28H36ClN5O3S
Molar mass558.14 g·mol−1
3D model (JSmol)
  • CC1=CC(=C(C=C1C2CCNCC2)OC(C)C)NC3=NC=C(C(=N3)NC4=CC=CC=C4S(=O)(=O)C(C)C)Cl
  • InChI=1S/C28H36ClN5O3S/c1-17(2)37-25-15-21(20-10-12-30-13-11-20)19(5)14-24(25)33-28-31-16-22(29)27(34-28)32-23-8-6-7-9-26(23)38(35,36)18(3)4/h6-9,14-18,20,30H,10-13H2,1-5H3,(H2,31,32,33,34)
  • Key:VERWOWGGCGHDQE-UHFFFAOYSA-N

Ceritinib (INN,[6] trade name Zykadia /zaɪˈkeɪdiːə/ zy-KAY-dee-ə) is a prescription-only drug used for the treatment of non-small cell lung cancer (NSCLC).[7] It was developed by Novartis and received FDA approval for use in April 2014.[7]

  1. ^ "Prescription medicines: registration of new chemical entities in Australia, 2016". Therapeutic Goods Administration (TGA). 21 June 2022. Archived from the original on 10 April 2023. Retrieved 10 April 2023.
  2. ^ "Health Canada New Drug Authorizations: 2015 Highlights". Health Canada. 4 May 2016. Retrieved 7 April 2024.
  3. ^ "Zykadia- ceritinib tablet, film coated". DailyMed. 11 January 2024. Retrieved 13 June 2024.
  4. ^ "Zykadia EPAR". European Medicines Agency. 6 May 2015. Retrieved 13 June 2024.
  5. ^ "Zykadia (ceritinib) Capsules, for Oral Use. Full Prescribing Information" (PDF). Novartis Pharmaceuticals Corporation. Retrieved 14 February 2017.
  6. ^ "International Nonproprietary Names for Pharmaceutical Substances (INN). Recommended International Nonproprietary Names: List 71" (PDF). World Health Organization. 2014. p. 79. Retrieved 14 February 2017.
  7. ^ a b "FDA Approves Ceritinib for ALK-Positive Lung Cancer". Medscape. 29 April 2014.