Ceruloplasmin

CP
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCP, CP-2, ceruloplasmin (ferroxidase), Ceruloplasmin, AB073614
External IDsOMIM: 117700; MGI: 88476; HomoloGene: 75; GeneCards: CP; OMA:CP - orthologs
EC number1.16.3.1
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000096

NM_001042611
NM_001276248
NM_001276250
NM_007752
NM_001374677

RefSeq (protein)

NP_000087

NP_001263177
NP_001263179
NP_031778
NP_001361606

Location (UCSC)Chr 3: 149.16 – 149.22 MbChr 3: 20.01 – 20.06 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ceruloplasmin (or caeruloplasmin) is a ferroxidase enzyme that in humans is encoded by the CP gene.[5][6][7]

Ceruloplasmin is the major copper-carrying protein in the blood, and in addition plays a role in iron metabolism. It was first described in 1948.[8] Another protein, hephaestin, is noted for its homology to ceruloplasmin, and also participates in iron and probably copper metabolism.

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000047457Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000003617Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Takahashi N, Ortel TL, Putnam FW (Jan 1984). "Single-chain structure of human ceruloplasmin: the complete amino acid sequence of the whole molecule". Proceedings of the National Academy of Sciences of the United States of America. 81 (2): 390–4. Bibcode:1984PNAS...81..390T. doi:10.1073/pnas.81.2.390. PMC 344682. PMID 6582496.
  6. ^ Koschinsky ML, Funk WD, van Oost BA, MacGillivray RT (Jul 1986). "Complete cDNA sequence of human preceruloplasmin". Proceedings of the National Academy of Sciences of the United States of America. 83 (14): 5086–90. Bibcode:1986PNAS...83.5086K. doi:10.1073/pnas.83.14.5086. PMC 323895. PMID 2873574.
  7. ^ Royle NJ, Irwin DM, Koschinsky ML, MacGillivray RT, Hamerton JL (May 1987). "Human genes encoding prothrombin and ceruloplasmin map to 11p11-q12 and 3q21-24, respectively". Somatic Cell and Molecular Genetics. 13 (3): 285–92. doi:10.1007/BF01535211. PMID 3474786. S2CID 45686258.
  8. ^ Holmberg CG, Laurell CB (1948). "Investigations in serum copper. II. Isolation of the Copper containing protein, and a description of its properties". Acta Chem Scand. 2: 550–56. doi:10.3891/acta.chem.scand.02-0550.