| Sport | Road bicycle racing |
|---|---|
| First season | 1948 |
| Ceased | 1958 |
| Replaced by | Super Prestige Pernod |
| Countries | International |
| Last champion(s) |  Fred De Bruyne (BEL) |
| Most titles |
|
The Challenge Desgrange-Colombo was a season-long road bicycle racing competition between 1948 and 1958. There were two classifications, one for individual cyclists and another for nations.