| Charles | |
|---|---|
 Portrait of Charles, Duke of Guise, by Justus Sustermans | |
| Duke of Guise | |
| Tenure | 23 December 1588 – 30 September 1640 |
| Predecessor | Henri I |
| Successor | Henri II |
| Born | August 20, 1571 Joinville |
| Died | 30 September 1640 (aged 69) Cuna |
| Spouse | Henriette Catherine of Joyeuse |
| Issue | |
| House | Guise |
| Father | Henri I, Duke of Guise |
| Mother | Catherine of Cleves |
Charles de Lorraine, 4th Duke of Guise and 3rd Prince of Joinville (20 August 1571 – 30 September 1640), was the son of Henry I, Duke of Guise and Catherine of Cleves, and succeeded his father as Duke of Guise in 1588. Initially part of the Catholic league, he pledged his support for Henry IV of France and was made Admiral of the Levant by Louis XIII of France. After siding with the Queen Mother, Marie de' Medici, against Cardinal Richelieu, he fled to Italy with his family where he died in 1640.