Charles Douglas may refer to:
- Charles Douglas, 3rd Duke of Queensberry (1698–1778), Scottish nobleman
- Charles Douglas, 6th Marquess of Queensberry (1777–1837), Scottish peer
- Charles Douglas, 5th Lord Mordington 18th-century Scottish peer
- Charles Douglas, 3rd Baron Douglas (1775–1848), English amateur cricketer
- Charles Douglas (mayor) (1852–1917), mayor of Vancouver and politician in Manitoba
- Sir Charles Douglas, 1st Baronet (1727–1789), Royal Navy officer
- Charles W. H. Douglas (1850–1914), former Chief of the Imperial General Staff of the British Army
- Charles Douglas III (born 1942), former congressman from New Hampshire
- Charles Douglas (musician), pseudonym of novelist and musician, Alex McAulay
- Charles Eurwicke Douglas (1806–1887), Member of Parliament for Warwick, 1837–1852, and Banbury, 1859–1865
- Charles Mackinnon Douglas (1865–1924), Member of Parliament for North West Lanarkshire, 1899–1906
- Charlie Douglas (1840–1916), New Zealand explorer and surveyor
- Charles F. Douglas (1833–1904), American architect from Maine