Chemotherapy-induced peripheral neuropathy

Chemotherapy-induced peripheral neuropathy
Other namesCIPN
SpecialtyNeurology

Chemotherapy-induced peripheral neuropathy (CIPN) is a nerve-damaging side effect of antineoplastic agents in the common cancer treatment, chemotherapy.[1] CIPN afflicts between 30% and 40% of patients undergoing chemotherapy. Antineoplastic agents in chemotherapy are designed to eliminate rapidly dividing cancer cells, but they can also damage healthy structures, including the peripheral nervous system.[1] CIPN involves various symptoms such as tingling, pain, and numbness in the hands and feet.[2] These symptoms can impair activities of daily living, such as typing or dressing, reduce balance, and increase risk of falls and hospitalizations. They can also give cause to reduce or discontinue chemotherapy. Researchers have conducted clinical trials and studies to uncover the various symptoms, causes, pathogenesis, diagnoses, risk factors, and treatments of CIPN.

  1. ^ a b Staff NP, Grisold A, Grisold W, Windebank AJ (June 2017). "Chemotherapy-induced peripheral neuropathy: A current review". Annals of Neurology. 81 (6): 772–781. doi:10.1002/ana.24951. PMC 5656281. PMID 28486769.
  2. ^ Loprinzi CL, Lacchetti C, Bleeker J, Cavaletti G, Chauhan C, Hertz DL, et al. (October 2020). "Prevention and Management of Chemotherapy-Induced Peripheral Neuropathy in Survivors of Adult Cancers: ASCO Guideline Update". Journal of Clinical Oncology. 38 (28): 3325–3348. doi:10.1200/JCO.20.01399. hdl:1805/27436. PMID 32663120. S2CID 220530836.