Chitinase

Chitinase
Serratia marcescens chitinase A dimer with bound inhibitor allosamidin. PDB: 1FFQ​
Identifiers
EC no.	3.2.1.14
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
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chitinase, acidic
Homo sapiens acidic mammalian chitinase with bound inhibitor methylallosamidin. PDB: 3FY1​
Identifiers
Symbol	CHIA
NCBI gene	27159
HGNC	17432
OMIM	606080
RefSeq	NM_001040623
UniProt	Q9BZP6
Other data
Locus	Chr. 1 p13.1-21.3
Search for Structures Swiss-model Domains InterPro

chitinase 1 (chitotriosidase)
Homo sapiens chitotriosidase bound with two molecules of inhibitor allosamidin PDB: 1HKK​
Identifiers
Symbol	CHIT1
NCBI gene	1118
HGNC	1936
OMIM	600031
RefSeq	NM_003465
UniProt	Q13231
Other data
Locus	Chr. 1 q31-q32
Search for Structures Swiss-model Domains InterPro

Chitinases (EC 3.2.1.14, chitodextrinase, 1,4-β-poly-N-acetylglucosaminidase, poly-β-glucosaminidase, β-1,4-poly-N-acetyl glucosamidinase, poly[1,4-(N-acetyl-β-D-glucosaminide)] glycanohydrolase, (1→4)-2-acetamido-2-deoxy-β-D-glucan glycanohydrolase; systematic name (1→4)-2-acetamido-2-deoxy-β-D-glucan glycanohydrolase) are hydrolytic enzymes that break down glycosidic bonds in chitin.^[1] They catalyse the following reaction:

Random endo-hydrolysis of N-acetyl-β-D-glucosaminide (1→4)-β-linkages in chitin and chitodextrins

As chitin is a component of the cell walls of fungi and exoskeletal elements of some animals (including mollusks and arthropods), chitinases are generally found in organisms that either need to reshape their own chitin^[2] or dissolve and digest the chitin of fungi or animals.