Cholesterol 7 alpha-hydroxylase

CYP7A1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3DAX, 3SN5, 3V8D
Identifiers
Aliases	CYP7A1, CP7A, CYP7, CYPVII, cytochrome P450 family 7 subfamily A member 1
External IDs	OMIM: 118455; MGI: 106091; HomoloGene: 30987; GeneCards: CYP7A1; OMA:CYP7A1 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	58,500,163 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	6,275,633 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; gonad; ; duodenum; ; subcutaneous adipose tissue; ; abdominal wall; ; spleen; ; gallbladder; ; mammary gland; ; lactiferous gland; ; tibial nerve;
	Top expressed in
	liver; ; left lobe of liver; ; lumbar subsegment of spinal cord; ; primary oocyte; ; secondary oocyte; ; gastrula; ; zygote; ; vestibular membrane of cochlear duct; ; trachea; ; lumbar spinal ganglion;
	More reference expression data
	n/a
Gene ontology
Molecular function	iron ion binding; metal ion binding; monooxygenase activity; heme binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; oxidoreductase activity; cholesterol 7-alpha-monooxygenase activity;
Cellular component	organelle membrane; endoplasmic reticulum membrane; intracellular membrane-bounded organelle; membrane; endoplasmic reticulum;
Biological process	steroid metabolic process; lipid metabolism; cholesterol metabolic process; cholesterol catabolic process; cellular response to cholesterol; regulation of bile acid biosynthetic process; sterol metabolic process; cholesterol homeostasis; bile acid biosynthetic process; cellular response to glucose stimulus; regulation of lipid metabolic process; positive regulation of cholesterol biosynthetic process; negative regulation of fatty acid biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	1581
	13122
	ENSG00000167910
	ENSMUSG00000028240
	P22680
	Q64505
	NM_000780
	NM_007824
	NP_000771
	NP_031850
	Wikidata
View/Edit Human	View/Edit Mouse

Cholesterol 7 alpha-hydroxylase also known as cholesterol 7-alpha-monooxygenase or cytochrome P450 7A1 (CYP7A1) is an enzyme that in humans is encoded by the CYP7A1 gene^[5] which has an important role in cholesterol metabolism. It is a cytochrome P450 enzyme, which belongs to the oxidoreductase class, and converts cholesterol to 7-alpha-hydroxycholesterol, the first and rate limiting step in bile acid synthesis.

The inhibition of cholesterol 7-alpha-hydroxylase (CYP7A1) represses bile acid biosynthesis.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000167910 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028240 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Cohen JC, Cali JJ, Jelinek DF, Mehrabian M, Sparkes RS, Lusis AJ, et al. (September 1992). "Cloning of the human cholesterol 7 alpha-hydroxylase gene (CYP7) and localization to chromosome 8q11-q12". Genomics. 14 (1): 153–161. doi:10.1016/S0888-7543(05)80298-8. PMID 1358792.
^ Miao J (2008). Regulation of Bile Acid Biosynthesis by Orphan Nuclear Receptor Small Heterodimer Partner (Ph.D.). University of Illinois at Urbana-Champaign.^{[permanent dead link]}

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000167910 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028240 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1358792-5] Cohen JC, Cali JJ, Jelinek DF, Mehrabian M, Sparkes RS, Lusis AJ, et al. (September 1992). "Cloning of the human cholesterol 7 alpha-hydroxylase gene (CYP7) and localization to chromosome 8q11-q12". Genomics. 14 (1): 153–161. doi:10.1016/S0888-7543(05)80298-8. PMID 1358792.

[6] Miao J (2008). Regulation of Bile Acid Biosynthesis by Orphan Nuclear Receptor Small Heterodimer Partner (Ph.D.). University of Illinois at Urbana-Champaign.^{[permanent dead link]}

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