Chorionic gonadotropin beta

CGB3
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	1HCN, 1HRP, 1QFW,%%s1QFW, 1HCN, 1HRP
Identifiers
Aliases	CGB3, CGB5, CGB7, CGB8, hCGB, CGB, Chorionic gonadotropin beta, chorionic gonadotropin beta subunit 3, Choriogonadotropin subunit beta, chorionic gonadotropin subunit beta 3, LHB, β-hCG
External IDs	HomoloGene: 37338; GeneCards: CGB3; OMA:CGB3 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	49,024,333 bp
RNA expression pattern
	Top expressed in
	placenta; ; testicle; ; pituitary gland; ; anterior pituitary; ; body of pancreas; ; duodenum; ; olfactory zone of nasal mucosa; ; granulocyte; ; right testis; ; left testis;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	hormone activity;
Cellular component	extracellular region; extracellular space; cytoplasm;
Biological process	peptide hormone processing; apoptotic process; signal transduction; female gamete generation; cell-cell signaling; regulation of transcription by RNA polymerase II; regulation of signaling receptor activity; hormone-mediated signaling pathway; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	1082
	n/a
	ENSG00000104827
	n/a
	P0DN86
	n/a
	NM_000737
	n/a
NP_000728.1; NP_149032.1; NP_149133.1; NP_149439.1; NP_149032;
	NP_149439
	n/a
	Wikidata
View/Edit Human

Choriogonadotropin subunit beta (CG-beta) also known as chorionic gonadotrophin chain beta is a protein that in humans is encoded by the CGB gene.^[3]^[4]^[5]

This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 3 subunit of chorionic gonadotropin (CG). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and a unique beta subunit which confers biological specificity. CG is produced by the trophoblastic cells of the placenta and stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. The beta subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13.3 and contiguous with the luteinizing hormone beta subunit gene.^[3]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000104827 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: chorionic gonadotropin".
^ Fiddes JC, Goodman HM (August 1980). "The cDNA for the beta-subunit of human chorionic gonadotropin suggests evolution of a gene by readthrough into the 3'-untranslated region". Nature. 286 (5774): 684–687. Bibcode:1980Natur.286..684F. doi:10.1038/286684a0. PMID 6774259. S2CID 4323775.
^ Policastro P, Ovitt CE, Hoshina M, Fukuoka H, Boothby MR, Boime I (October 1983). "The beta subunit of human chorionic gonadotropin is encoded by multiple genes". The Journal of Biological Chemistry. 258 (19): 11492–11499. doi:10.1016/S0021-9258(17)44254-2. PMID 6194155.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000104827 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-3] "Entrez Gene: chorionic gonadotropin".

[pmid6774259-4] Fiddes JC, Goodman HM (August 1980). "The cDNA for the beta-subunit of human chorionic gonadotropin suggests evolution of a gene by readthrough into the 3'-untranslated region". Nature. 286 (5774): 684–687. Bibcode:1980Natur.286..684F. doi:10.1038/286684a0. PMID 6774259. S2CID 4323775.

[pmid6194155-5] Policastro P, Ovitt CE, Hoshina M, Fukuoka H, Boothby MR, Boime I (October 1983). "The beta subunit of human chorionic gonadotropin is encoded by multiple genes". The Journal of Biological Chemistry. 258 (19): 11492–11499. doi:10.1016/S0021-9258(17)44254-2. PMID 6194155.

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