| Chromosome 8 | |
|---|---|
 Human chromosome 8 pair after G-banding. One is from mother, one is from father. | |
 Chromosome 8 pair in human male karyogram. | |
| Features | |
| Length (bp) | 146,259,331 (CHM13)[1] |
| No. of genes | 646 (CCDS)[2] |
| Type | Autosome |
| Centromere position | Submetacentric[3] (45.2 Mbp[4]) |
| Complete gene lists | |
| CCDS | Gene list |
| HGNC | Gene list |
| UniProt | Gene list |
| NCBI | Gene list |
| External map viewers | |
| Ensembl | Chromosome 8 |
| Entrez | Chromosome 8 |
| NCBI | Chromosome 8 |
| UCSC | Chromosome 8 |
| Full DNA sequences | |
| RefSeq | NC_000008 (FASTA) |
| GenBank | CM000670 (FASTA) |
Chromosome 8 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 8 spans about 146 million base pairs (the building material of DNA) and represents between 4.5 and 5.0% of the total DNA in cells.[5]
About 8% of its genes are involved in brain development and function, and about 16% are involved in cancer. A unique feature of 8p is a region of about 15 megabases that appears to have a high mutation rate. This region shows a significant divergence between human and chimpanzee, suggesting that its high mutation rates have contributed to the evolution of the human brain.[5]
- ^ "Homo sapiens isolate CHM13 chromosome 8". National Library of Medicine /accessdate=2023-01-13. 4 April 2022.
- ^ Cite error: The named reference
CCDSwas invoked but never defined (see the help page). - ^ Tom Strachan; Andrew Read (2 April 2010). Human Molecular Genetics. Garland Science. p. 45. ISBN 978-1-136-84407-2.
- ^ Genome Decoration Page, NCBI. Ideogram data for Homo sapience (850 bphs, Assembly GRCh38.p3). Last update 2014-06-03. Retrieved 2017-04-26.
- ^ a b Tabarés-Seisdedos R, Rubenstein JL; Rubenstein (2009). "Chromosome 8p as a potential hub for developmental neuropsychiatric disorders: implications for schizophrenia, autism and cancer". Mol Psychiatry. 14 (6): 563–89. doi:10.1038/mp.2009.2. PMID 19204725. S2CID 11118479.