Cidofovir

Cidofovir
Clinical data
Trade namesVistide
AHFS/Drugs.comMonograph
Pregnancy
category
  • AU: D
Routes of
administration		Intravenous
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailabilitycomplete
Protein binding<6%
Elimination half-life2.6 hours (active metabolites: 15–65 hours)
Excretionrenal The above pharmacokinetic parameters are measured for cidofovir used in conjunction with probenecid.[3]
Identifiers
  • ({[(S)-1-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3-hydroxypropan-2-yl]oxy}methyl)phosphonic acid
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
NIAID ChemDB
CompTox Dashboard (EPA)
ECHA InfoCard100.166.433 Edit this at Wikidata
Chemical and physical data
FormulaC8H14N3O6P
Molar mass279.189 g·mol−1
3D model (JSmol)
Specific rotation-97.3
Melting point260 °C (500 °F)
  • O=C1/N=C(\C=C/N1C[C@H](OCP(=O)(O)O)CO)N
  • InChI=1S/C8H14N3O6P/c9-7-1-2-11(8(13)10-7)3-6(4-12)17-5-18(14,15)16/h1-2,6,12H,3-5H2,(H2,9,10,13)(H2,14,15,16)/t6-/m0/s1 checkY
  • Key:VWFCHDSQECPREK-LURJTMIESA-N checkY
  (verify)

Cidofovir, brand name Vistide, is a topical or injectable antiviral medication primarily used as a treatment for cytomegalovirus (CMV) retinitis (an infection of the retina of the eye) in people with AIDS.[4][5]

Cidofovir was approved for medical use in 1996.[6]

  1. ^ "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 Oct 2023.
  2. ^ "Drug and medical device highlights 2018: Helping you maintain and improve your health". Health Canada. 14 October 2020. Retrieved 17 April 2024.
  3. ^ Cundy, Kenneth C. "Clinical Pharmacokinetics of the Antiviral Nucleotide Analogues Cidofovir and Adefovir." Clinical Pharmacokinetics 36.2 (1999): 127–143.
  4. ^ Cite error: The named reference MSR was invoked but never defined (see the help page).
  5. ^ Cite error: The named reference TGA was invoked but never defined (see the help page).
  6. ^ Long SS, Prober CG, Fischer M (2012). Principles and Practice of Pediatric Infectious Disease. Elsevier Health Sciences. p. 1502. ISBN 978-1437727029.