Cilostazol

Cilostazol
Clinical data
Pronunciation/sɪˈlɒstəzɒl/
sil-OS-tə-zol
Trade namesPletal
AHFS/Drugs.comMonograph
MedlinePlusa601038
License data
Routes of
administration		By mouth (tablets)
ATC code
Legal status
Legal status
  • AU: S4 (Prescription only)
  • UK: POM (Prescription only)
  • US: WARNING[1]Rx-only
Pharmacokinetic data
Protein binding95–98%
MetabolismLiver (CYP3A4- and CYP2C19-mediated)
Elimination half-life11–13 hours
ExcretionKidney
Identifiers
  • 6-[4-(1-Cyclohexyl-1H-tetrazol-5-yl)butoxy]-
    3,4-dihydro-2(1H)-quinolinone
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.215.897 Edit this at Wikidata
Chemical and physical data
FormulaC20H27N5O2
Molar mass369.469 g·mol−1
3D model (JSmol)
  • O=C4Nc3c(cc(OCCCCc1nnnn1C2CCCCC2)cc3)CC4
  • InChI=1S/C20H27N5O2/c26-20-12-9-15-14-17(10-11-18(15)21-20)27-13-5-4-8-19-22-23-24-25(19)16-6-2-1-3-7-16/h10-11,14,16H,1-9,12-13H2,(H,21,26) checkY
  • Key:RRGUKTPIGVIEKM-UHFFFAOYSA-N checkY
  (verify)

Cilostazol, sold under the brand name Pletal among others, is a medication used to help the symptoms of intermittent claudication in peripheral vascular disease.[2] If no improvement is seen after 3 months, stopping the medication is reasonable.[3] It may also be used to prevent stroke.[2] It is taken by mouth.[2]

Common side effects include headache, diarrhea, dizziness, and cough.[2] Serious side effects may include decreased survival in those with heart failure, low platelets, and low white blood cells.[2] Cilostazol is a phosphodiesterase 3 inhibitor which works by inhibiting platelet aggregation and dilating arteries.[2]

Cilostazol was approved for medical use in the United States in 1999.[2] It is available as a generic medication.[3] In 2019, it was the 347th most commonly prescribed medication in the United States, with more than 800 thousand prescriptions.[4]

  1. ^ "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 Oct 2023.
  2. ^ a b c d e f g "Cilostazol Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 23 March 2019.
  3. ^ a b British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. pp. 231–232. ISBN 9780857113382.
  4. ^ "Cilostazol - Drug Usage Statistics". ClinCalc. Retrieved 7 October 2022.