The Clatsop Mission was an outpost of the Methodist Mission near modern Astoria, Oregon, United States. Joseph H. Frost and his family was sent to the Clatsop Plains at the mouth of the Columbia River in 1841. Frustrated at his inability to convert the local Clatsop and Nehalem people, Frost took his family and left the area in August 1843. Josiah Parrish was appointed as his replacement, working at the station until its closure the following year in 1844.