Clindamycin/tretinoin

Clindamycin/tretinoin
Combination of
Clindamycin phosphateAntibiotic
TretinoinTopical retinoid
Clinical data
Trade namesZiana, others
MedlinePlusa609005
Routes of
administration		Topical
ATC code
Legal status
Legal status
  • In general: ℞ (Prescription only)
Identifiers
CAS Number
KEGG
  (verify)

Clindamycin/tretinoin is a topical gel used in the treatment of acne. The two active ingredients are the antibiotic clindamycin phosphate (1.2%) and tretinoin (0.025%), a retinoid.[1] The two active ingredients perform different functions, the clindamycin is active against gram-positive bacteria, including streptococci and penicillin-resistant staphylococci.[2] The Tretinoin element acts to reduce the amount of oil released by oil glands in skin, as well as encouraging skin cell replenishment.[3] The topical treatment is stored in 2, 30, and 60 gram tubes and should be stored at 25°C (77°F), with the tube tightly shut away from light.[4] Side effects may include peeling, redness, dryness, itching and photosensitivity. Also, topical clindamycin may rarely cause diarrhea or colitis. Sun exposure while using this preparation can cause skin irritation.[5]

  1. ^ "Ziana Gel". Retrieved 16 November 2008.
  2. ^ "BNF is only available in the UK". NICE. Retrieved 5 October 2021.
  3. ^ Zasada M, Budzisz E (August 2019). "Retinoids: active molecules influencing skin structure formation in cosmetic and dermatological treatments". Postepy Dermatologii I Alergologii. 36 (4): 392–397. doi:10.5114/ada.2019.87443. PMC 6791161. PMID 31616211.
  4. ^ "Ziana Prescribing Information" (PDF). Archived from the original (PDF) on 17 June 2007. Retrieved 15 November 2008.
  5. ^ Kurokawa I (19 May 2016). "Faculty Opinions recommendation of Guidelines of care for the management of acne vulgaris". doi:10.3410/f.726161029.793518600. {{cite journal}}: Cite journal requires |journal= (help)