Clobetasol propionate

Not to be confused with Clostebol propionate.

Clobetasol propionate
Clinical data
Pronunciation/kloʊˈbeɪtəsɒl/[1]
Trade namesDermovate, Temovate, Clovate, others
AHFS/Drugs.comMonograph
License data
Pregnancy
category
  • AU: B3
Routes of
administration		Topical
ATC code
Legal status
Legal status
  • US: WARNING[2]
  • In general: ℞ (Prescription only)
Identifiers
  • [17-(2'-Chloroacetyl)-9-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.042.380 Edit this at Wikidata
Chemical and physical data
FormulaC25H32ClFO5
Molar mass466.97 g·mol−1
3D model (JSmol)
  • ClCC(=O)[C@]3(OC(=O)CC)[C@]2(C[C@H](O)[C@]4(F)[C@@]/1(\C(=C/C(=O)\C=C\1)CC[C@H]4[C@@H]2C[C@@H]3C)C)C
  • InChI=1S/C25H32ClFO5/c1-5-21(31)32-25(20(30)13-26)14(2)10-18-17-7-6-15-11-16(28)8-9-22(15,3)24(17,27)19(29)12-23(18,25)4/h8-9,11,14,17-19,29H,5-7,10,12-13H2,1-4H3/t14-,17-,18-,19-,22-,23-,24-,25-/m0/s1 checkY
  • Key:CBGUOGMQLZIXBE-XGQKBEPLSA-N checkY
  (verify)

Clobetasol propionate is a corticosteroid used to treat skin conditions such as eczema, contact dermatitis, seborrheic dermatitis, steroid responsive dermatosis, and psoriasis (including scalp and plaque-type).[3][4][5]

It is applied to the skin as a cream, foam, gel, liquid, solution, ointment, or shampoo.[4][6][5] Use should be short term and only if other weaker corticosteroids are not effective.[6] Use is not recommended in rosacea or perioral dermatitis.[4]

Common side effects include skin irritation, dry skin, redness, pimples, and telangiectasia.[4] Serious side effects may include adrenal suppression, allergic reactions, cellulitis, and Cushing's syndrome.[4] Use in pregnancy and breastfeeding is of unclear safety.[7] Clobetasol is believed to work by activating steroid receptors.[4]

Clobetasol propionate was patented in 1968 and came into medical use in 1978.[8] It is available as a generic medication.[6] In 2022, it was the 156th most commonly prescribed medication in the United States, with more than 3 million prescriptions.[9][10]

  1. ^ "Clobetasol Propionate Topical Ointment 0.05% Information". Drug Encyclopedia. Kaiser Permanente. Archived from the original on 28 August 2021. Retrieved 9 October 2009.
  2. ^ "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 October 2023.
  3. ^ "DailyMed: Betasol dipropionate". NIH.gov.
  4. ^ a b c d e f "Clobetasol Propionate Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 28 August 2021. Retrieved 13 April 2019.
  5. ^ a b "Clobetasol (topical): Drug information". UpToDate. 2024.
  6. ^ a b c British National Formulary: BNF 76 (76th ed.). Pharmaceutical Press. 2018. p. 1210. ISBN 978-0-85711-338-2.
  7. ^ "Clobetasol topical Use During Pregnancy". Drugs.com. Archived from the original on 28 August 2021. Retrieved 13 April 2019.
  8. ^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 487. ISBN 9783527607495. Archived from the original on 28 November 2023. Retrieved 3 September 2020.
  9. ^ "The Top 300 of 2022". ClinCalc. Archived from the original on 30 August 2024. Retrieved 30 August 2024.
  10. ^ "Clobetasol Drug Usage Statistics, United States, 2013 - 2022". ClinCalc. Retrieved 30 August 2024.