Clodronic acid

Clodronic acid
Clinical data
AHFS/Drugs.com	International Drug Names
ATC code	M05BA02 (WHO) ;
Legal status
Legal status	CA: ℞-only;
Identifiers
	IUPAC name (Dichloro-phosphono-methyl)phosphonic acid;
CAS Number	10596-23-3 ;
PubChem CID	25419;
DrugBank	DB00720 ;
ChemSpider	23731 ;
UNII	0813BZ6866;
KEGG	D03545 ;
ChEBI	CHEBI:110423 ;
ChEMBL	ChEMBL12318 ;
CompTox Dashboard (EPA)	DTXSID8046959 ;
ECHA InfoCard	100.031.090
Chemical and physical data
Formula	CH4Cl2O6P2
Molar mass	244.88 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES ClC(Cl)(P(=O)(O)O)P(=O)(O)O;
	InChI InChI=1S/CH4Cl2O6P2/c2-1(3,10(4,5)6)11(7,8)9/h(H2,4,5,6)(H2,7,8,9) ; Key:ACSIXWWBWUQEHA-UHFFFAOYSA-N ;
	(verify)

Clodronic acid (INN) or clodronate disodium (Na₂CH₂Cl₂O₆P₂) (USAN) is a first generation (non-nitrogenous) bisphosphonate. It is an anti-osteoporotic drug approved for the prevention and treatment of osteoporosis in post-menopausal women and men to reduce vertebral fractures, hyperparathyroidism, hypercalcemia in malignancy, multiple myeloma and fracture related pain because of its anti-inflammatory effects shown as a reduction in inflammatory markers like IL-1β, IL-6, and TNF-α.^[1]

^ Pennanen N, Lapinjoki S, Urtti A, Mönkkönen J (June 1995). "Effect of liposomal and free bisphosphonates on the IL-1 beta, IL-6 and TNF alpha secretion from RAW 264 cells in vitro". Pharmaceutical Research. 12 (6): 916–22. doi:10.1023/A:1016281608773. PMID 7667201. S2CID 46332840.

[1] Pennanen N, Lapinjoki S, Urtti A, Mönkkönen J (June 1995). "Effect of liposomal and free bisphosphonates on the IL-1 beta, IL-6 and TNF alpha secretion from RAW 264 cells in vitro". Pharmaceutical Research. 12 (6): 916–22. doi:10.1023/A:1016281608773. PMID 7667201. S2CID 46332840.

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