Cloperastine

Cloperastine
Clinical data
Other names	HT-11
AHFS/Drugs.com	International Drug Names
Routes of; administration	Oral
ATC code	R05DB21 (WHO) ;
Identifiers
	IUPAC name 1-[2-[(4-Chlorophenyl)-phenyl-methoxy]ethyl]piperidine;
CAS Number	3703-76-2 ;
PubChem CID	2805;
DrugBank	DB09002 ;
ChemSpider	2703 ;
UNII	69M5L7BXEK;
KEGG	D03557 ;
ChEMBL	ChEMBL415087 ;
CompTox Dashboard (EPA)	DTXSID7048532 ;
ECHA InfoCard	100.020.948
Chemical and physical data
Formula	C20H24ClNO
Molar mass	329.87 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Clc1ccc(cc1)C(OCCN2CCCCC2)c3ccccc3;
	InChI InChI=1S/C20H24ClNO/c21-19-11-9-18(10-12-19)20(17-7-3-1-4-8-17)23-16-15-22-13-5-2-6-14-22/h1,3-4,7-12,20H,2,5-6,13-16H2 ; Key:FLNXBVJLPJNOSI-UHFFFAOYSA-N ;
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Cloperastine (INN) or cloperastin, in the forms of cloperastine hydrochloride (JAN) (brand names Hustazol, Nitossil, Seki) and cloperastine fendizoate, is an antitussive and antihistamine that is marketed as a cough suppressant in Japan, Hong Kong, and in some European countries.^[1]^[2]^[3] It was first introduced in 1972 in Japan, and then in Italy in 1981.^[4]

^ Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 301–. ISBN 978-1-4757-2085-3.
^ Swiss Pharmaceutial Society, ed. (January 2000). Index Nominum 2000: International Drug Directory. Taylor & Francis. pp. 261–. ISBN 978-3-88763-075-1.
^ Catania MA, Cuzzocrea S (2011). "Pharmacological and clinical overview of cloperastine in treatment of cough". Therapeutics and Clinical Risk Management. 7: 83–92. doi:10.2147/TCRM.S16643. PMC 3061847. PMID 21445282.
^ William Andrew Publishing (22 October 2013). Pharmaceutical Manufacturing Encyclopedia. Elsevier. pp. 1103–. ISBN 978-0-8155-1856-3.

[Elks2014-1] Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 301–. ISBN 978-1-4757-2085-3.

[2] Swiss Pharmaceutial Society, ed. (January 2000). Index Nominum 2000: International Drug Directory. Taylor & Francis. pp. 261–. ISBN 978-3-88763-075-1.

[CuzzocreaCatania2011-3] Catania MA, Cuzzocrea S (2011). "Pharmacological and clinical overview of cloperastine in treatment of cough". Therapeutics and Clinical Risk Management. 7: 83–92. doi:10.2147/TCRM.S16643. PMC 3061847. PMID 21445282.

[Publishing2013-4] William Andrew Publishing (22 October 2013). Pharmaceutical Manufacturing Encyclopedia. Elsevier. pp. 1103–. ISBN 978-0-8155-1856-3.

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