Cold turkey refers to the abrupt cessation of substance use in the context of substance dependence, as opposed to gradually easing the process through reduction over time or by using replacement medication. Sudden withdrawal from drugs such as alcohol, benzodiazepines, and barbiturates can be extremely dangerous, leading to potentially fatal seizures. For long-term alcoholics, going cold turkey can cause life-threatening delirium tremens.[1] In the case of opioid withdrawal, going "cold turkey" is extremely unpleasant but less dangerous.[2][3] Life-threatening issues are unlikely unless one has a pre-existing medical condition.[3]