| Clinical data | |
|---|---|
| Trade names | Xiaflex, Xiapex, Qwo |
| Other names | AA-4500, collagenase clostridium histolyticum-aaes |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a612029 |
| License data | |
| Routes of administration | Intralesional injection |
| ATC code | |
| Legal status | |
| Legal status | |
| Identifiers | |
| CAS Number | |
| PubChem SID | |
| DrugBank | |
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| UNII | |
| KEGG | |
| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.029.608 |
| Chemical and physical data | |
| Molar mass | 114 kg/mol (AUX-I) 113 kg/mol (AUX-II) |
  (what is this?) (verify) | |
Collagenase clostridium histolyticum is an enzyme produced by the bacterium Clostridium histolyticum that dismantles collagen. It is used as a powder-and-solvent injection kit for the treatment of Dupuytren's contracture, a condition where the fingers bend towards the palm and cannot be fully straightened, and Peyronie's disease, a connective tissue disorder involving the growth of fibrous plaques in the soft tissue of the penis. BioSpecifics Technologies developed the preparation, which is manufactured and marketed by Endo Pharmaceuticals as Xiaflex in the US and by Sobi as Xiapex in Europe.
Biochemically, it is a mixture of two C. histolyticum collagenases, ColH and ColG. A similar ointment preparation called Santyl contains one or many collagenases from the same bacterium, but it is unclear which.[2]
- ^ "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 Oct 2023.
- ^ "Collagenase ColH of Hathewaya histolytica (Clostridium histolyticum) [Q46085]". UniProt. Retrieved 26 December 2020.