Collins oxidation

This article is about the oxidation reaction. For the oxidizing reagent, see Collins reagent.
Collins oxidation
Named after Joseph C. Collins
Reaction type Organic redox reaction
Identifiers
RSC ontology ID RXNO:0000550

The Collins oxidation is an organic reaction for the oxidation of primary alcohols to aldehydes. It is distinguished from other chromium oxide-based oxidations by the use of Collins reagent, a complex of chromium(VI) oxide with pyridine in dichloromethane.[1][2]

Mechanism of the Collins oxidation[3]
Mechanism of the Collins oxidation[3]
  1. ^ J. C. Collins, W. W. Hess and F. J. Frank (1968). "Dipyridine-chromium(VI) oxide oxidation of alcohols in dichloromethane". Tetrahedron Lett. 9 (30): 3363–3366. doi:10.1016/S0040-4039(00)89494-0.
  2. ^ J. C. Collins, W.W. Hess (1988). "Aldehydes from Primary Alcohols by Oxidation with Chromium Trioxide: Heptanal". Organic Syntheses; Collected Volumes, vol. 6, p. 644.
  3. ^ "17.7: Oxidation of Alcohols". Chemistry LibreTexts. 2015-08-26. Retrieved 2022-12-09.