Common gamma chain

IL2RG
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2B5I, 2ERJ, 3BPL, 3QAZ, 3QB7, 4GS7
Identifiers
Aliases	IL2RG, CD132, CIDX, IL-2RG, IMD4, P64, SCIDX, SCIDX1, interleukin 2 receptor subunit gamma
External IDs	OMIM: 308380; MGI: 96551; HomoloGene: 172; GeneCards: IL2RG; OMA:IL2RG - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xq13.1 Start 71,107,404 bp[1] End 71,112,108 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X D|X 43.9 cM Start 100,307,984 bp[2] End 100,311,861 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte lymph node appendix rectum thymus spleen bone marrow cells mucosa of ileum blood jejunal mucosa Top expressed in mesenteric lymph nodes thymus spleen blood decidua granulocyte right lung right lung lobe subcutaneous adipose tissue left lung More reference expression data BioGPS More reference expression data
Gene ontology Molecular function interleukin-7 receptor activity interleukin-2 receptor activity protein binding cytokine receptor activity interleukin-4 receptor activity interleukin-2 binding cytokine binding interleukin-15 receptor activity Cellular component integral component of membrane membrane plasma membrane integral component of plasma membrane external side of plasma membrane endosome cytosol cell surface receptor complex Biological process MAPK cascade immune response viral process signal transduction interleukin-2-mediated signaling pathway interleukin-4-mediated signaling pathway interleukin-7-mediated signaling pathway interleukin-15-mediated signaling pathway interleukin-9-mediated signaling pathway regulation of molecular function cytokine-mediated signaling pathway interleukin-21-mediated signaling pathway positive regulation of phagocytosis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3561 16186 Ensembl ENSG00000147168 ENSMUSG00000031304 UniProt P31785 P34902 RefSeq (mRNA) NM_000206 NM_013563 NM_001308535 RefSeq (protein) NP_000197 NP_001295464 NP_038591 Location (UCSC) Chr X: 71.11 – 71.11 Mb Chr X: 100.31 – 100.31 Mb PubMed search [3] [4]
Wikidata
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The common gamma chain (γ_c) (or CD132), also known as interleukin-2 receptor subunit gamma or IL-2RG, is a cytokine receptor sub-unit that is common to the receptor complexes for at least six different interleukin receptors: IL-2, IL-4,^[5] IL-7,^[6] IL-9, IL-15^[7] and interleukin-21 receptor. The γ_c glycoprotein is a member of the type I cytokine receptor family expressed on most lymphocyte (white blood cell) populations, and its gene is found on the X-chromosome of mammals.

This protein is located on the surface of immature blood-forming cells in bone marrow. One end of the protein resides outside the cell where it binds to cytokines and the other end of the protein resides in the interior of the cell where it transmits signals to the cell's nucleus. The common gamma chain partners with other proteins to direct blood-forming cells to form lymphocytes (a type of white blood cell). The receptor also directs the growth and maturation of lymphocyte subtypes: T cells, B cells, and natural killer cells. These cells kill viruses, make antibodies, and help regulate the entire immune system.