Complement component 2

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C2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2I6S, 3ERB,%%s2ODQ
Identifiers
Aliases	C2, ARMD14, CO2, complement component 2, complement C2
External IDs	OMIM: 613927; MGI: 88226; HomoloGene: 45; GeneCards: C2; OMA:C2 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.33 Start 31,897,785 bp[1] End 31,945,673 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 B1|17 18.41 cM Start 35,081,580 bp[2] End 35,117,241 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in liver right lobe of liver placenta spleen upper lobe of left lung gallbladder appendix right lung lymph node duodenum Top expressed in iris decidua adrenal gland white adipose tissue left lobe of liver tunica adventitia of aorta lumbar spinal ganglion mesenteric lymph nodes sciatic nerve ileum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase activity serine-type peptidase activity hydrolase activity metal ion binding serine-type endopeptidase activity protein binding Cellular component extracellular region extracellular exosome extracellular space Biological process complement activation positive regulation of apoptotic cell clearance regulation of complement activation response to nutrient proteolysis complement activation, classical pathway immune system process innate immune response Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 717 12263 Ensembl ENSG00000206372 ENSG00000235017 ENSG00000235696 ENSG00000226560 ENSG00000204364 ENSG00000166278 ENSG00000231543 ENSMUSG00000024371 UniProt P06681 Q5JP69 P21180 RefSeq (mRNA) NM_000063 NM_001145903 NM_001178063 NM_001282457 NM_001282458 NM_001282459 NM_013484 RefSeq (protein) NP_000054 NP_001139375 NP_001171534 NP_001269386 NP_001269387 NP_001269388 NP_000054.2 NP_038512 Location (UCSC) Chr 6: 31.9 – 31.95 Mb Chr 17: 35.08 – 35.12 Mb PubMed search [3] [4]
Wikidata
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Complement C2 is a protein that in humans is encoded by the C2 gene.^[5] The protein encoded by this gene is part of the classical pathway of the complement system, acting as a multi-domain serine protease. Deficiency of C2 has been associated with certain autoimmune diseases.^[5]

The Complement system is generated to regulate self protection from infection. The overall Complement system is composed of protein groups that collaborate in destroying foreign invaders, which ultimately remove debris from cells and tissues. When the body detects a foreign invader, the body signals the Complement system and the Complement component 2 protein attaches to Complement system 4 resulting in an immune response. Complement component 2 protein is critical for regulating the body's immune response.