Complement component 9

C9
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesC9, ARMD15, C9D, complement component 9, complement C9
External IDsOMIM: 120940; MGI: 1098282; HomoloGene: 74406; GeneCards: C9; OMA:C9 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001737

NM_013485
NM_001368420
NM_001368421

RefSeq (protein)

NP_001728

NP_038513
NP_001355349
NP_001355350

Location (UCSC)Chr 5: 39.28 – 39.37 MbChr 15: 6.47 – 6.53 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Complement component 9 (C9) is a MACPF protein involved in the complement system, which is part of the innate immune system.[5] Once activated, about 12-18 molecules of C9 polymerize to form pores in target cell membranes, causing lysis and cell death.[6] C9 is one member of the complement membrane attack complex (MAC), which also includes complement components C5b, C6, C7 and C8.[7][8][9]  The formation of the MAC occurs through three distinct pathways: the classical, alternative, and lectin pathways.[7] Pore formation by C9 is an important way that bacterial cells are killed during an infection, and the target cell is often covered in multiple MACs. The clinical impact of a deficiency in C9 is an infection with the gram-negative bacterium Neisseria meningitidis.[10]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000113600Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022149Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Lint TF, Zeitz HJ, Gewurz H (November 1980). "Inherited deficiency of the ninth component of complement in man". Journal of Immunology. 125 (5): 2252–7. doi:10.4049/jimmunol.125.5.2252. PMID 7430628.
  6. ^ Dudkina NV, Spicer BA, Reboul CF, Conroy PJ, Lukoyanova N, Elmlund H, et al. (February 2016). "Structure of the poly-C9 component of the complement membrane attack complex". Nature Communications. 7 (1): 10588. Bibcode:2016NatCo...710588D. doi:10.1038/ncomms10588. PMC 4742998. PMID 26841934.
  7. ^ a b Mohapatra A, Das S, Dey S, Sahoo PK (April 2020). "Molecular characterization and induced expression analysis of the terminal complement component C9 in rohu, Labeo rohita". Aquaculture Research. 51 (4): 1415–1427. doi:10.1111/are.14487. ISSN 1355-557X. S2CID 213565293.
  8. ^ Spicer BA, Law RH, Caradoc-Davies TT, Ekkel SM, Bayly-Jones C, Pang SS, et al. (August 2018). "The first transmembrane region of complement component-9 acts as a brake on its self-assembly". Nature Communications. 9 (1): 3266. Bibcode:2018NatCo...9.3266S. doi:10.1038/s41467-018-05717-0. PMC 6093860. PMID 30111885.
  9. ^ Wickramaarachchi WD, Wan Q, Lee Y, Lim BS, De Zoysa M, Oh MJ, et al. (October 2012). "Genomic characterization and expression analysis of complement component 9 in rock bream (Oplegnathus fasciatus)". Fish & Shellfish Immunology. 33 (4): 707–17. doi:10.1016/j.fsi.2012.06.019. PMID 22796422.
  10. ^ Fu X, Ju J, Lin Z, Xiao W, Li X, Zhuang B, et al. (July 2016). "Target deletion of complement component 9 attenuates antibody-mediated hemolysis and lipopolysaccharide (LPS)-induced acute shock in mice". Scientific Reports. 6 (1): 30239. Bibcode:2016NatSR...630239F. doi:10.1038/srep30239. PMC 4957234. PMID 27444648.