Consanguine marriage is marriage between individuals who are closely related. Though it may involve incest, it implies more than the sexual nature of incest. In a clinical sense, marriage between two family members who are second cousins or closer qualifies as consanguineous marriage. This is based on the gene copies their offspring may receive.[1] Though these unions are still prevalent in some communities, as seen across the Greater Middle East region, many other populations have seen a great decline in intra-family marriages.[2]