Constitutive androstane receptor

NR1I3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1XVP, 1XV9
Identifiers
Aliases	NR1I3, CAR, CAR1, MB67, nuclear receptor subfamily 1 group I member 3
External IDs	OMIM: 603881; MGI: 1346307; HomoloGene: 3759; GeneCards: NR1I3; OMA:NR1I3 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q23.3 Start 161,229,666 bp[1] End 161,238,244 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 H3|1 79.21 cM Start 171,041,539 bp[2] End 171,048,270 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver testicle buccal mucosa cell gonad nucleus accumbens human kidney muscle of thigh caudate nucleus gastrocnemius muscle putamen Top expressed in left lobe of liver duodenum gallbladder entorhinal cortex epithelium of small intestine Ileal epithelium perirhinal cortex choroid plexus of fourth ventricle CA3 field jejunum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding sequence-specific DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific transcription coactivator activity zinc ion binding metal ion binding steroid hormone receptor activity nuclear receptor activity DNA-binding transcription factor activity, RNA polymerase II-specific transcription cis-regulatory region binding transcription factor binding nuclear receptor coactivator activity signaling receptor activity Cellular component cytoplasm cytosol nucleoplasm cytoskeleton nucleus RNA polymerase II transcription regulator complex Biological process regulation of transcription, DNA-templated transcription, DNA-templated transcription initiation from RNA polymerase II promoter negative regulation of transcription, DNA-templated signal transduction positive regulation of transcription by RNA polymerase II steroid hormone mediated signaling pathway androgen receptor signaling pathway intracellular receptor signaling pathway multicellular organism development cell differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9970 12355 Ensembl ENSG00000143257 ENSMUSG00000005677 UniProt Q14994 Q6GZ81 O35627 RefSeq (mRNA) NM_001077469 NM_001077470 NM_001077471 NM_001077472 NM_001077473 NM_001077474 NM_001077475 NM_001077476 NM_001077477 NM_001077478 NM_001077479 NM_001077480 NM_001077481 NM_001077482 NM_005122 NM_001243062 NM_001243063 NM_009803 RefSeq (protein) NP_001070937 NP_001070938 NP_001070939 NP_001070940 NP_001070941 NP_001070942 NP_001070943 NP_001070944 NP_001070945 NP_001070946 NP_001070947 NP_001070948 NP_001070949 NP_001070950 NP_005113 NP_001229991 NP_001229992 NP_033933 Location (UCSC) Chr 1: 161.23 – 161.24 Mb Chr 1: 171.04 – 171.05 Mb PubMed search [3] [4]
Wikidata
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The constitutive androstane receptor (CAR) also known as nuclear receptor subfamily 1, group I, member 3 is a protein that in humans is encoded by the NR1I3 gene.^[5] CAR is a member of the nuclear receptor superfamily and along with pregnane X receptor (PXR) functions as a sensor of endobiotic and xenobiotic substances. In response, expression of proteins responsible for the metabolism and excretion of these substances is upregulated.^[6] Hence, CAR and PXR play a major role in the detoxification of foreign substances such as drugs.

Androstenol and several isomers of androstanol, androstanes, are endogenous antagonists of the CAR, and despite acting as antagonists, were the basis for the naming of this receptor.^[7] More recently, dehydroepiandrosterone (DHEA), also an androstane, has been found to be an endogenous agonist of the CAR.^[8]