Cornforth rearrangement

In organic chemistry, the Cornforth rearrangement is a rearrangement reaction of a 4-acyloxazole in which the group attached to an acyl on position 4 and the substituent on position 5 of an oxazole ring exchange places.[1] It was first reported in 1949, and is named for John Cornforth. The reaction is used in the synthesis of amino acids, where the corresponding oxazoles occur as intermediates.[2]

  1. ^ Dewar, Michael J. S.; Turchi, Ignatius J. (1974). "The Cornforth Rearrangement". Journal of the American Chemical Society. 96 (19): 6148–6152. doi:10.1021/ja00826a030.
  2. ^ Kürti, László (2005). Strategic applications of named reactions in organic synthesis : background and detailed mechanisms. Barbara Czakó. Amsterdam: Elsevier Academic Press. pp. 112–113. ISBN 978-0-12-429785-2. OCLC 60792519.