Corticosterone

Corticosterone
Corticosterone molecule
Names
IUPAC name
11β,21-Dihydroxypregn-4-ene-3,20-dione
Systematic IUPAC name
(1S,3aS,3bS,9aR,9bS,10S,11aS)-10-Hydroxy-1-(hydroxyacetyl)-9a,11a-dimethyl-1,2,3,3a,3b,4,5,8,9,9a,9b,10,11,11a-tetradecahydro-7H-cyclopropa[a]phenanthren-7-one
Identifiers
3D model (JSmol)
2339601
ChEBI
ChEMBL
ChemSpider
DrugBank
ECHA InfoCard 100.000.018 Edit this at Wikidata
EC Number
  • 200-019-6
KEGG
MeSH Corticosterone
UNII
  • InChI=1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1 checkY
    Key: OMFXVFTZEKFJBZ-HJTSIMOOSA-N checkY
  • InChI=1/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1
    Key: OMFXVFTZEKFJBZ-HJTSIMOOBD
  • O=C4\C=C2/[C@]([C@H]1[C@@H](O)C[C@@]3([C@@H](C(=O)CO)CC[C@H]3[C@@H]1CC2)C)(C)CC4
Properties
C21H30O4
Molar mass 346.467 g·mol−1
Hazards
GHS labelling:
GHS07: Exclamation mark
Warning
H317
P261, P272, P280, P302+P352, P321, P333+P313, P363, P501
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
☒N verify (what is checkY☒N ?)

Corticosterone, also known as 17-deoxycortisol and 11β,21-dihydroxyprogesterone,[1] is a 21-carbon steroid hormone of the corticosteroid type produced in the cortex of the adrenal glands. In the very rare case of congenital adrenal hyperplasia due to 17α-hydroxylase deficiency cortisol production is blocked.[2]

  1. ^ R.A. Hill; H.L.J. Makin; D.N. Kirk; G.M. Murphy (23 May 1991). Dictionary of Steroids. CRC Press. pp. 189–. ISBN 978-0-412-27060-4.
  2. ^ "C-17 Hydroxylase Deficiency: Practice Essentials, Pathophysiology, Epidemiology". 1 February 2018 – via eMedicine. {{cite journal}}: Cite journal requires |journal= (help)