Cortistatin (neuropeptide)

CORT
Identifiers
Aliases	CORT, CST-14, CST-17, CST-29, cortistatin, SST2
External IDs	OMIM: 602784; MGI: 109538; HomoloGene: 997; GeneCards: CORT; OMA:CORT - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.22 Start 10,450,031 bp[1] End 10,451,998 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 E2|4 78.89 cM Start 149,209,491 bp[2] End 149,211,220 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in putamen caudate nucleus prefrontal cortex nucleus accumbens superior frontal gyrus anterior cingulate cortex gonad temporal lobe amygdala Brodmann area 9 Top expressed in embryo primary visual cortex embryo dentate gyrus of hippocampal formation granule cell superior frontal gyrus hippocampus proper fetal liver hematopoietic progenitor cell perirhinal cortex tail of embryo olfactory bulb More reference expression data BioGPS n/a
Gene ontology Molecular function neuropeptide hormone activity G protein-coupled receptor binding hormone activity chromatin binding double-stranded DNA binding Cellular component extracellular region Fanconi anaemia nuclear complex FANCM-MHF complex extracellular space Biological process adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway chemical synaptic transmission mitotic recombination resolution of meiotic recombination intermediates interstrand cross-link repair replication fork processing regulation of signaling receptor activity G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1325 12854 Ensembl ENSG00000241563 ENSMUSG00000028971 UniProt O00230 P56469 RefSeq (mRNA) NM_001302 NM_007745 RefSeq (protein) NP_001293 NP_031771 Location (UCSC) Chr 1: 10.45 – 10.45 Mb Chr 4: 149.21 – 149.21 Mb PubMed search [3] [4]
Wikidata
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Precortistatin is a protein that in humans is encoded by the CORT gene.^[5][6] The 105 amino acid residue human precortistatin in turn is cleaved into cortistatin-17 and cortistatin-29. Cortistatin-17 is the only active peptide derived from the precursor.^[5] Cortistatin (or more specifically cortistatin-17) is a neuropeptide that is expressed in inhibitory neurons of the cerebral cortex, and which has a strong structural similarity to somatostatin. Unlike somatostatin, when infused into the brain, it enhances slow-wave sleep. It binds to sites in the cortex, hippocampus and the amygdala.