Cot filtration

C₀t filtration, or CF, is a technique that uses the principles of DNA renaturation kinetics (i.e. Cot analysis) to separate the repetitive DNA sequences that dominate many eukaryotic genomes from "gene-rich" single/low-copy sequences.^[1]^[2] This allows DNA sequencing to concentrate on the parts of the genome that are most informative and interesting.

^ Peterson DG (2005) Reduced representation strategies and their application to plant genomes. In: The Handbook of Plant Genome Mapping: Genetic and Physical Mapping. Edited by: Meksem K, Kahl G. WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. pp. 307-335.
^ Lamoureux D, Peterson DG, Li W, Fellers JP, Gill BS (2005) The efficacy of Cot-based gene enrichment in wheat (Triticum aestivum L.). Genome 48: 1120-1126.

[1] Peterson DG (2005) Reduced representation strategies and their application to plant genomes. In: The Handbook of Plant Genome Mapping: Genetic and Physical Mapping. Edited by: Meksem K, Kahl G. WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. pp. 307-335.

[2] Lamoureux D, Peterson DG, Li W, Fellers JP, Gill BS (2005) The efficacy of Cot-based gene enrichment in wheat (Triticum aestivum L.). Genome 48: 1120-1126.

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