Cotton Creek is a stream in Oregon County in the Ozarks of southern Missouri.[1] It is a tributary of Frederick Creek.[2]
The stream headwaters are at 36°32′52″N 91°16′33″W / 36.54778°N 91.27583°W and the confluence wit Frederick Creek is at 36°35′04″N 91°14′38″W / 36.58444°N 91.24389°W.[1]
Cotton Creek was so named on account of cotton fields near its course.[3]