Crystallin

Not to be confused with Crystalline.

In anatomy, a crystallin is a water-soluble structural protein found in the lens and the cornea of the eye accounting for the transparency of the structure.[1] It has also been identified in other places such as the heart, and in aggressive breast cancer tumors.[2][3] The physical origins of eye lens transparency and its relationship to cataract are an active area of research. [4] Since it has been shown that lens injury may promote nerve regeneration,[5] crystallin has been an area of neural research. So far, it has been demonstrated that crystallin β b2 (crybb2) may be a neurite-promoting factor.[6]

  1. ^ Jester JV (2008). "Corneal crystallins and the development of cellular transparency". Seminars in Cell & Developmental Biology. 19 (2): 82–93. doi:10.1016/j.semcdb.2007.09.015. PMC 2275913. PMID 17997336.
  2. ^ Lutsch G, Vetter R, Offhauss U, Wieske M, Gröne HJ, Klemenz R, Schimke I, Stahl J, Benndorf R (1997). "Abundance and location of the small heat shock proteins HSP25 and alphaB-crystallin in rat and human heart". Circulation. 96 (10): 3466–3476. doi:10.1161/01.cir.96.10.3466. PMID 9396443.
  3. ^ Moyano JV, Evans JR, Chen F, Lu M, Werner ME, Yehiely F, Diaz LK, Turbin D, Karaca G, Wiley E, Nielsen TO, Perou CM, Cryns VL (2005). "B-Crystallin is a novel oncoprotein that predicts poor clinical outcome in breast cancer". Journal of Clinical Investigation. 116 (1): 261–270. doi:10.1172/JCI25888. PMC 1323258. PMID 16395408.
  4. ^ Panda, Alok Kumar; Nandi, Sandip Kumar; Chakraborty, Ayon; Nagaraj, Ram H.; Biswas, Ashis (1 January 2016). "Differential role of arginine mutations on the structure and functions of α-crystallin". Biochimica et Biophysica Acta (BBA) - General Subjects. 1860 (1, Part B): 199–210. doi:10.1016/j.bbagen.2015.06.004. PMC 4914040. PMID 26080000.
  5. ^ Fischer D, Pavlidis M, Thanos S (2000). "Cataractogenic lens injury prevents traumatic ganglion cell death and promotes axonal regeneration both in vivo and in culture". Investigative Ophthalmology & Visual Science. 41 (12): 3943–3954. PMID 11053298.
  6. ^ Liedtke T, Schwamborn JC, Schröer U, Thanos S (2007). "Elongation of Axons during Regeneration Involves Retinal Crystallin b2 (crybb2)". Molecular & Cellular Proteomics. 6 (5): 895–907. doi:10.1074/mcp.M600245-MCP200. PMID 17264069.